ArticleNPJ microgravity2019
Inflight leg cuff test does not identify the risk for orthostatic hypotension after long-duration spaceflight.
Article in NPJ microgravity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- DI-5-Cuffs: Lumbar Intervertebral Disc Proteoglycan and Water Content Changes in Humans after Five Days of Dry Immersion to Simulate Microgravity.International journal of molecular sciences · 2020Trial
- A combined individualized cycling exercise and artificial gravity training protocol as a spaceflight deconditioning countermeasure.NPJ microgravity · 2025Article
- Plasticity of the heart in response to changes in physical activity.The Journal of physiology · 2025Review
- Lower body negative pressure identifies altered central vein characteristics without accompanying changes to baroreflexes in astronauts within hours of landing.Scientific reports · 2024Article
- Influence of a Passive Tilt Test on the Proteomic Composition of the Blood of Healthy Humans.Bulletin of experimental biology and medicine · 2024Article
- Running vs. resistance exercise to counteract deconditioning induced by 90-day head-down bedrest.Frontiers in physiology · 2022Article
- Implementation of exercise countermeasures during spaceflight and microgravity analogue studies: Developing countermeasure protocols for bedrest in older adults (BROA).Frontiers in physiology · 2022Review
- Efficacy of Gradient Compression Garments in the Hours After Long-Duration Spaceflight.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Landing day symptoms from orthostatic hypotension after prolonged spaceflight can be debilitating, but severity of these symptoms can be unpredictable and highly individual. We tested the hypothesis that an impaired baroreflex response to an inflight leg cuff test could predict orthostatic intolerance on return to Earth. Eight male astronauts (44 ± 7 years of age (mean ± SD); mean mission length: 167 ± 12 days) participated in a standardized supine-to-sit-to-stand test (5 min-30s-3 min) pre- and postflight, and a 3 min thigh cuff occlusion test pre- and inflight with continuous monitoring of heart rate and arterial blood pressure. The arterial baroreflex was not changed inflight as shown by similar reductions in mean arterial pressure (MAP) response to leg cuff deflation (preflight -19 ± 2 mmHg vs. inflight -18 ± 5 mmHg). With the sit/stand test, the nadir of MAP was lower postflight (-17 ± 9 mmHg) than preflight (-11 ± 6 mmHg,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.