Evidence map›Paper›PMID 31632977›Full record

ReviewFrontiers in nutrition2019

Toward New Paradigms in the Follow Up of Adult Patients With Celiac Disease on a Gluten-Free Diet.

Maria I Pinto-Sanchez, Julio C Bai

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04788797 (Effect of the Endopeptidase AN-PEP on Gluten Exposure in Real Life in Celiac Disease Patients Treated With a Long-term Gluten-free Diet. Exploratory, Interventional, Prospective, Controlled and Double Blind Study), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04788797 phase4completednot on this mapstarted 2021, after this paper: background citation

Effect of the Endopeptidase AN-PEP on Gluten Exposure in Real Life in Celiac Disease Patients Treated With a Long-term Gluten-free Diet. Exploratory, Interventional, Prospective, Controlled and Double Blind Study

TypeinterventionalSponsorDr. C. Bonorino Udaondo Gastroenterology HospitalRan2021 to 2022Enrolled40ConditionsCeliac DiseaseArmsProlyl Endopeptidase, Placebo
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Telemedicine in Coeliac Disease: In-Person Appointments Are Favoured by Patients With a Lower Education Attainment and Lower Household Income.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Article
  5. Article
  6. Article
  7. [Adherence factors to the gluten-free diet in people with celiac disease in Paraguay]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2024
    Observational
  8. Article
  9. Review
  10. Article
  11. The Effects of Gluten on Weight Gain, Hematological, Biochemical, and Various Endocrinological Parameters.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Bone mineral density in Iranian children with celiac disease.Gastroenterology and hepatology from bed to bench · 2023
    Article
  16. Article
  17. Review article: Follow-up of coeliac disease.Alimentary pharmacology & therapeutics · 2022
    Review
  18. Observational
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Maria I Pinto-SanchezDepartment of Medicine, Gastroenterology Division, McMaster University Medical Center, Hamilton, ON, Canada.
Julio C BaiResearch Institute, Universidad del Salvador, Buenos Aires, Argentina.
McMaster University Medical Centre · CAUniversidad del Salvador · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gluten free diet is the only available treatment for celiac disease (CeD). Patients with CeD who do not adhere to a strict gluten-free diet (GFD) have been found to have complications involving nutritional deficiencies, increased risk of bone fractures, increased risk of mortality, and certain types of cancers. Complete removal of gluten from the diet in a patient with CeD often results in symptomatic, serologic, and histologic remission. However, strict compliance with the diet is challenging. Long-term follow-up care is needed to assure treatment compliance and positive health outcomes. Monitoring celiac specific serology, nutrient deficiencies, bone mineral density, and assessment of GFD compliance have been recommended in clinical practice. However, there is no consensus on which specific tests and how often they should be performed during the follow up. Here, we have performed a review of the literature on current strategies to follow up patients with CeD. There are new tools for monitoring adherence to the GFD which could change some paradigms in following up treated patients.

Indexed as

antibodiesbiopsyceliac diseasefollow-upgluten-free diet

Identifiers

PMID31632977
PMCPMC6781794
OpenAlexW2977473347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.