ArticleSpinal cord series and cases2019
Restoration of hand function with long-term paired associative stimulation after chronic incomplete tetraplegia: a case study.
Article in Spinal cord series and cases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-term Paired Associative Stimulation in Rehabilitation of Spinal Cord Injury Patients
Paired Associative Stimulation in Subacute Spinal Cord Injury
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Modulations in neural pathways excitability post transcutaneous spinal cord stimulation among individuals with spinal cord injury: a systematic review.Frontiers in neuroscience · 2024Pooled it
- Paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component in treatment of neuropathic pain after incomplete spinal cord injury - a pilot trial.Spinal cord series and cases · 2026Trial
- Paired associative stimulation improves outcomes when applied at the subacute stage after incomplete cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Improving hand function in chronic incomplete tetraplegia by high-PAS intervention with alternative equipment: a case report.Spinal cord series and cases · 2026Article
- Heart rate variability in patients with incomplete spinal cord injury during a single session of paired associative stimulation.Scientific reports · 2025Article
- nTMS in spinal cord injury: Current evidence, challenges and a future direction.Brain & spine · 2025Review
- Stable improvement in hand muscle strength in incomplete spinal cord injury patients by long-term paired associative stimulation-a case series study.Frontiers in neurology · 2025Article
- Spinally targeted paired associated stimulation with high-frequency peripheral component induces spinal level plasticity in healthy subjects.Scientific reports · 2024Article
- The effect of paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component on heart rate and heart rate variability in healthy subjects.Frontiers in rehabilitation sciences · 2023Article
- Article
- Optimal peripheral nerve stimulation intensity for paired associative stimulation with high-frequency peripheral component in healthy subjects.Scientific reports · 2022Article
- Effect of long-term paired associative stimulation on the modulation of cortical sensorimotor oscillations after spinal cord injury.Spinal cord series and cases · 2022Article
- A New Paired Associative Stimulation Protocol with High-Frequency Peripheral Component and High-Intensity 20 Hz Repetitive Transcranial Magnetic Stimulation-A Pilot Study.International journal of environmental research and public health · 2021Article
- Plasticity in Cervical Motor Circuits following Spinal Cord Injury and Rehabilitation.Biology · 2021Review
- Omitting TMS component from paired associative stimulation with high-frequency PNS: A case series of tetraplegic patients.Clinical neurophysiology practice · 2021Article
- The impact of TMS and PNS frequencies on MEP potentiation in PAS with high-frequency peripheral component.PloS one · 2020Article
- Effects of Long-Term Paired Associative Stimulation on Strength of Leg Muscles and Walking in Chronic Tetraplegia: A Proof-of-Concept Pilot Study.Frontiers in neurology · 2020Article
- Paired associative stimulation improves hand function after non-traumatic spinal cord injury: A case series.Clinical neurophysiology practice · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: This case study explores the gains in hand function in an individual with a chronic spinal cord injury (SCI). The intervention was long-term paired associative simulation (PAS). We aimed to provide PAS until full recovery of hand muscle strength occurred, or until improvements ceased. Case presentation: A 46-year-old man with traumatic C7 AIS B tetraplegia was administered PAS three times per week. After 24 weeks, PAS was combined with concomitant motor training of the remaining weak hand muscles. Outcome measures included the manual muscle test (MMT), motor-evoked potentials (MEPs), F-responses, hand functional tests, and the spinal cord independence measure (SCIM). Discussion: After 47 weeks of PAS the subject had improved self-care and indoor mobility and was able to perform complex motor tasks (SCIM score improved from 40 to 56). His left hand regained maximum MMT score (total 75; increase of score from baseline condition 19); the effect remained stable in the 32-week follow up. In the right-hand muscles, MMT scores of 4-5 were observed in follow up (total 71; increase from baseline 48). Improved values were also observed in other outcomes. This is the first demonstration of long-term PAS restoring muscle strength corresponding to MMT scores of 4-5 in an individual with chronic SCI. The effect persisted for several months, indicating that PAS induces stable plastic changes in the corticospinal pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.