ArticleAmerican journal of translational research2019
Associations between single nucleotide polymorphisms in miR-221, self-reported essential hypertension, and interactions between genetic and environmental factors: a multiethnic study in China.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 2 citations in OpenAlex.
- Family History of Hypertension and Cobalt Exposure Synergistically Promote the Prevalence of Hypertension.Biological trace element research · 2022Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
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Abstract
This case-control study explored the relationship between SNPs in miR-221 and self-reported essential hypertension, as well as interactions between genetic and environmental factors, in a multiethnic Chinese cohort. A MassArray analysis was performed to genotype 462 patients with essential hypertension and 442 healthy participants. The association between four SNPs in miR-221 and essential hypertension risk was determined by investigating the differences in allelic and genotypic frequencies between case and control groups using PLINK version 1.07 software. A 4 × 2 table approach was conducted to explore the synergistic effect of SNPs and environmental factors on the risk of essential hypertension. Subjects with the C allele of rs2858060 in miR-221 had a lower risk of essential hypertension than those with the G allele (OR = 0.692; 95% CI = 0.521-0.920; P = 0.011). Logistic regression analysis showed that carriers of the CC genotype had a significantly lower risk of essential hypertension than those with the homozygous GG genotype (OR = 0.679; 95% CI = 0.498-0.925; P = 0.014). Using crossover analyses, we identified significant interactions between rs2858060 and the effect of age, triglycerides, HDL-C, ApoB, and fasting blood glucose on essential hypertension risk. We conclude that rs2858060 in miR-221 is associated with essential hypertension risk in the Chinese population, with a clear interaction between rs2858060 and classical risk factors in predicting the condition. Therefore, rs2858060 in miR-221 could play an important role as a genetic risk factor for the development of essential hypertension in the Chinese population.
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Identifiers
31632582PMC6789256W2993334898What OpenQuestion holds
Registered trials
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