ArticleAmerican journal of translational research2019
MiR-27b targets PI3K p110α to inhibit proliferation and migration in colorectal cancer stem cell.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A Review.Global medical genetics · 2023Review
- Milk Exosomal miR-27b Worsen Endoplasmic Reticulum Stress Mediated Colorectal Cancer Cell Death.Nutrients · 2022Article
- LINC01234 regulates microRNA-27b-5p to induce the migration, invasion and self-renewal of ovarian cancer stem cells through targeting SIRT5.Cell cycle (Georgetown, Tex.) · 2022Article
- Effects of hsa-miR-28-5p on Adriamycin Sensitivity in Diffuse Large B-Cell Lymphoma.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Sevoflurane inhibits cell proliferation and migration of glioma by targeting the miR‑27b/VEGF axis.Molecular medicine reports · 2021Article
- MSI1 Promotes the Expression of the GBM Stem Cell Marker CD44 by Impairing miRNA-Dependent Degradation.Cancers · 2020Article
- lncRNA TTN‑AS1 upregulates RUNX1 to enhance glioma progression via sponging miR‑27b‑3p.Oncology reports · 2020Article
- MicroRNA-196b-5p promotes malignant progression of colorectal cancer by targeting ING5.Cancer cell international · 2020Article
- LncRNA LINC00511 Acts as an Oncogene in Colorectal Cancer via Sponging miR-29c-3p to Upregulate NFIA.OncoTargets and therapy · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide, CRC was estimated to be the third most commonly diagnosed cancer and a leading cause of cancer deaths in developed countries due to therapy resistance and metastasis. Cancer stem cells (CSCs) were found in a variety of malignant tumors, including colorectal cancer. miR-27b play pivotal roles in the acquisition of CSC properties such as tumor initiation, drug resistance and asymmetric cell division. The aim of the present study was to investigate the underlying mechanisms that miR-27b inhibits proliferation, invasion and migration of CSCs. In present study, miR-27b were found to be significantly upregulated in CSCs. Overexpression of miR-27b inhibit CSCs proliferation and migration. In addition, overexpression of miR-27b suppress the character expression of CSCs, including of CD44, CD133, Sox2 and Oct4. Furthermore, it has been demonstrated that miR-27b is directly targeted by PIK3CA and miR-27b overexpression can effectively attenuate the expression of Phosphor-PI3K p110α and phosphor-Akt. In conclusion, these results reveal that PIK3CA is significantly downregulated by miR-27b expression in CSCs. Thus, we presume that miR-27b may be a therapeutic anti-tumor agent for CRC via targeting PI3K p110α.
Indexed as
Identifiers
31632566PMC6789227W2989605660What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.