ArticleAmerican journal of translational research2019
Nobiletin alleviates cerebral ischemic-reperfusion injury via MAPK signaling pathway.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Artificial Intelligence for Natural Products Drug Discovery in Neurodegenerative Therapies: A Review.Biomolecules · 2026Review
- L-tetrahydropalmatine attenuates ketamine reward effect via modulating the miR-27a-3p/MAP2K4 axis.Frontiers in genetics · 2026Article
- Natural products derived from traditional Chinese medicines targeting ER stress for the treatment of kidney diseases.Renal failure · 2024Review
- Nobiletin restores HFD-induced enteric nerve injury by regulating enteric glial activation and the GDNF/AKT/FOXO3a/P21 pathway.Molecular medicine (Cambridge, Mass.) · 2024Article
- Exploring Chinese herbal medicine for ischemic stroke: insights into microglia and signaling pathways.Frontiers in pharmacology · 2024Review
- A review on recent advances on nobiletin in central and peripheral nervous system diseases.European journal of medical research · 2023Review
- Review
- Neuroprotective effects of nobiletin on cerebral ischemia/reperfusion injury rats by inhibiting Rho/ROCK signaling pathway.Annals of translational medicine · 2022Article
- Role of circadian rhythms in pathogenesis of acute CNS injuries: Insights from experimental studies.Experimental neurology · 2022Review
- Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review).International journal of molecular medicine · 2022Review
- Nobiletin prevents amyloid βMetabolic brain disease · 2022Article
- Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway.Nutrients · 2022Article
- The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke.Molecules (Basel, Switzerland) · 2022Review
- KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway.Frontiers in pharmacology · 2022Article
- Nobiletin ameliorates cardiac impairment and alleviates cardiac remodeling after acute myocardial infarction in rats via JNK regulation.Pharmacology research & perspectives · 2021Article
- Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders.Nutrients · 2021Review
- Article
- The Application ofEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Nobiletin alleviates ischemia/reperfusion injury in the kidney by activating PI3K/AKT pathway.Molecular medicine reports · 2020Article
- Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways.Biomedicines · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNobiletin (NOB), isolated from Citrus nobilis, has been reported to inhibit cerebral ischemia/reperfusion (I/R) induced cell apoptosis in the brain. The mechanisms and the protective ability of NOB on cerebral I/R rats are unclear.
methodsA middle cerebral artery occlusion (MCAO) rat model was established and treated with different doses of NOB. The neurological deficits, brain water content and brain index were explored after reperfusion, and TTC staining was applied to assess the infarct area. The production of reactive oxygen species (ROS) related enzymes in the ischemic cortex samples from each group was measured. TUNEL staining was performed to evaluate neuronal cell apoptosis in brain tissues. The expression of cell apoptosis related proteins, p-p38 and MAPKAP-2 and the levels of inflammatory factors were examined by western blotting assay and ELISA.
resultsNOB treatment notably improved the neurological deficits, brain water content and brain index in an MCAO model, accompanied by decreased infarct area in the brain tissue. Apoptosis induced by cerebral I/R was also decreased by NOB administration via upregulating Bcl-2 and downregulating Bax and caspase3. The levels of pro-inflammatory mediators TNF-α, IL-6 were reduced and anti-inflammatory cytokine IL-10 was increased by NOB treatment in MCAO rats. Further, we found that the expression of p-p38 and MAPKAP-2 was reduced by NOB treatment in MCAO rats.
conclusionThe present results suggest that NOB serves a protective role in I/R-induced cerebral-neuron injury. The mechanisms underlying these effects may be associated with the MAPK signaling pathway.
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Identifiers
31632564PMC6789284W2992212549What OpenQuestion holds
Registered trials
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