ArticleAmerican journal of translational research2019
Expression profile of circular RNA s in TMJ osteoarthritis synovial tissues and potential functions of hsa_circ_0000448 with specific back-spliced junction.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Molecular mediators of motion: RNA-RBP networks in exercise-induced osteoarthritis protection.Frontiers in genetics · 2026Review
- Epigenetic Biomarkers in Temporomandibular Joint Osteoarthritis: An Emerging Target in Treatment.International journal of molecular sciences · 2025Review
- Potential pathological and molecular mechanisms of temporomandibular joint osteoarthritis.Journal of dental sciences · 2023Review
- Whole-transcriptome sequencing and ceRNA interaction network of temporomandibular joint osteoarthritis.Frontiers in genetics · 2022Article
- Overexpression of hsa_circ_0094742 inhibits IL-1β-induced decline in CHON-001 cell viability by targeting microRNA-127-5p.Histology and histopathology · 2021Article
- Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications.Arthritis research & therapy · 2021Review
- An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis.Stem cells international · 2021Review
- Circular RNA in osteoarthritis: an updated insight into the pathophysiology and therapeutics.American journal of translational research · 2021Review
- Crosstalk Among circRNA/lncRNA, miRNA, and mRNA in Osteoarthritis.Frontiers in cell and developmental biology · 2021Review
- CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-α in TMJ osteoarthritis.Cell death & disease · 2020Article
- Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAs essential players in the occurrence and development of osteoarthritis, circular RNAs (circRNAs) have gradually received attention in recent years. However, their roles in temporomandibular joint osteoarthritis (TMJOA) featured with pain, restricted mouth opening and joint movement dysfunction, remains elusive.
methodsThe expression profile of circRNAs in TMJ synovial tissues was analyzed by RNA-Seq. The differentially expressed circRNAs in the TMJOA were identified. The potential biological functions of these circRNAs were evaluated.
resultsThe expression profile of circRNAs in TMJ synovial tissues was stable and abundant, and most of which were newly discovered. A total of 58 differentially expressed circRNAs were identified in TMJOA, and four of which were identified by
conclusioncircRNAs in TMJ synovial tissue participate in the progression of TMJOA and may become a potential therapeutic target. The highly up-regulated has_circ_0000448 probably promotes TNF-α secretion of synovium through CeRNA mechanism in TMJOA.
Indexed as
Identifiers
31632516PMC6789216W2983093034What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.