ArticleFrontiers in neuroscience2019
Increased Maternal Prenatal Adiposity, Inflammation, and Lower Omega-3 Fatty Acid Levels Influence Child Negative Affect.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- The Role of Empathy in ADHD Children: Neuropsychological Assessment and Possible Rehabilitation Suggestions-A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Higher prenatal dietary glycemic index in the third trimester of pregnancy is associated with infant negative affect at 6 months.Scientific reports · 2025Article
- Infant buccal telomere length: associations with maternal distress in pregnancy and offspring temperament.Frontiers in public health · 2025Article
- Pre-pregnancy overweight or obesity moderates the association between prenatal maternal depressive symptoms and infant cord blood omega-3 levels.BMC pregnancy and childbirth · 2024Article
- Adipokines measured during pregnancy and at birth are associated with infant negative affect.Brain, behavior, and immunity · 2024Article
- Delineating early developmental pathways to ADHD: Setting an international research agenda.JCPP advances · 2023Article
- Associations between the human immune system and gut microbiome with neurodevelopment in the first 5 years of life: A systematic scoping review.Developmental psychobiology · 2023Article
- Epigenetics and ADHD: Reflections on Current Knowledge, Research Priorities and Translational Potential.Molecular diagnosis & therapy · 2022Article
- Parsing ADHD with Temperament Traits.Current directions in psychological science · 2022Article
- The Influence of Maternal Metabolic State and Nutrition on Offspring Neurobehavioral Development: A Focus on Preclinical Models.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Maternal diet and obesity shape offspring central and peripheral inflammatory outcomes in juvenile non-human primates.Brain, behavior, and immunity · 2022Article
- Electroencephalogram aperiodic power spectral slope can be reliably measured and predicts ADHD risk in early development.Developmental psychobiology · 2022Article
- Association of Prepregnancy Obesity and Remodeled Maternal-Fetal Plasma Fatty Acid Profiles.Frontiers in nutrition · 2022Article
- Understanding Vulnerability and Adaptation in Early Brain Development using Network Neuroscience.Trends in neurosciences · 2021Review
- Development of ADHD: Etiology, Heterogeneity, and Early Life Course.Annual review of developmental psychology · 2020Article
- Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development.Journal of clinical medicine · 2020Review
- Pre-pregnancy body mass index and parent and teacher-reported behavioral outcomes among offspring in childhood.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIncreased maternal adiposity during pregnancy is associated with offspring risk for psychiatric disorders. Inflammation secondary to adiposity is believed to be an important mechanism through which this effect occurs. Although increased adiposity introduces risk, not all children of overweight mothers develop these problems. Gestational factors that modify this risk are not well-understood. If maternal increased adiposity exerts its effects on offspring outcomes by increasing inflammation in the gestational environment, then anti-inflammatory inputs such as omega-3 fatty acids may be one protective factor. The goal of this study was to investigate whether maternal pre-pregnancy body mass index (BMI) and omega-3 fatty acid levels independently and/or interactively predicted offspring infant negative affect, an early life marker of risk for psychopathology.
methodsData came from a prospective study of women recruited during pregnancy and their 6 month old infants (
resultsMaternal pre-pregnancy BMI was associated with increased infant negative affect whereas eicosapentaenoic acid was associated with less infant negative affect. Maternal omega-3 fatty acid levels moderated the effect of BMI on infant negative affect, such that omega-3 fatty acids buffered children against the negative consequences of increased adiposity. Supporting the role of maternal inflammation in these associations, maternal BMI and omega-3 fatty acid levels interacted to predict maternal third trimester inflammation. Further, maternal inflammation was associated with increased infant negative affect.
conclusionResults suggest that omega-3 supplementation during pregnancy may protect against offspring behavioral risk associated with increased maternal adiposity.
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Registered trials
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