Evidence map›Paper›PMID 31632192›Full record

ArticleSleep and biological rhythms2019

Brief behavioral treatment for insomnia in older adults with late-life treatment-resistant depression and insomnia: a pilot study.

Marie Anne Gebara, Elizabeth A DiNapoli, Lisa G Lederer, Adam D Bramoweth, Anne Germain, John W Kasckow, Jordan F Karp

Open access · greenAbstract read
In one paragraph

Article in Sleep and biological rhythms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Late Life Depression: The Essentials and the Essential Distinctions.Focus (American Psychiatric Publishing) · 2021
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Marie Anne GebaraDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; USA.
Elizabeth A DiNapoliMental Illness Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA; USA.
Lisa G LedererMental Illness Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA; USA.
Adam D BramowethMental Illness Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA; USA.
Anne GermainDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; USA.
John W KasckowVA Beckley Healthcare System, Beckley, West Virginia; USA.
Jordan F KarpDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; USA.
University of Pittsburgh · USVA Pittsburgh Healthcare System · USBeckley VA Medical Center · US

Funding

Pharmacologic MRI Predictors of Treatment Response in Late-Life DepressionR01MH076079 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, ANDREESCU, CARMEN · 2006 to 2022
$7.1M
CLINICAL RESEARCH TRAINING IN LATE-LIFE MOOD DISORDERST32MH019986 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Carmen Andreescu · 1997 to 2026
$6.9M
Implementation of Brief Treatments for Insomnia in Primary CareIK2HX001548 · VA · VETERANS HEALTH ADMINISTRATION · PI BRAMOWETH, ADAM DANIEL · 2018 to 2020
–
HSRD VA IK2 HX001548NIMH NIH HHS R01 MH076079NIMH NIH HHS T32 MH019986
6 · The paper itself

Abstract

objectiveBrief Behavioral Treatment for Insomnia (BBTI) is an efficacious treatment of insomnia in older adults. Behavioral treatments for insomnia can also improve depression. However, it is unknown if BBTI is feasible or has an effect in patients with insomnia and late-life treatment resistant depression (LLTRD). The aims of this study were two-fold, to test: 1) the feasibility (defined by acceptability and retention rates) of BBTI and 2) the therapeutic potency of BBTI on symptoms of insomnia and depression.

methodsEleven older Veterans with LLTRD and insomnia were recruited in a randomized control trial to receive immediate (4-weeks of BBTI followed by 3-weeks of phone call check-ins and a final in-person 8-week assessment) or delayed (3-weeks of treatment as usual [wait-list control] followed by 4-weeks of BBTI and a final in-person 8-week assessment) BBTI. The primary outcome measures included the Patient Health Questionnaire (minus the sleep item) and the Insomnia Severity Index.

resultsBBTI was found to be feasible in older Veterans with insomnia and LLTRD; all participants recommended BBTI and retention rates were 90.9%. There was no difference in treatment effect between the immediate BBTI and delayed BBTI groups at week 4. After both groups (immediate and delayed) received BBTI, improvements were seen in both insomnia (

conclusionsBBTI is a feasible treatment for insomnia in older adults with LLTRD. BBTI may be an effective adjunctive treatment for depression. Larger adequately-powered trials are required to confirm these preliminary findings.

Indexed as

agingBehavioral treatmentinsomniatreatment resistant depression

Identifiers

PMID31632192
PMCPMC6800686
OpenAlexW2914641489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.