Evidence map›Paper›PMID 31631993›Full record

ArticleClinical interventions in aging2019

Immunogenicity And Safety Of The 13-Valent Pneumococcal Conjugate Vaccine In Patients With Monoclonal Gammopathy Of Undetermined Significance - Relationship With Selected Immune And Clinical Parameters.

Marcin Pasiarski, Barbara Sosnowska-Pasiarska, Ewelina Grywalska, Agnieszka Stelmach-Gołdyś, Artur Kowalik, Stanisław Góźdź, Jacek Roliński

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical interventions in aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Marcin PasiarskiDepartment of Hematology, Holycross Cancer Center, Kielce, Poland.
Barbara Sosnowska-PasiarskaDepartment of Oncocardiology, Holycross Cancer Center, Kielce, Poland.
Ewelina GrywalskaDepartment of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.ORCID 0000-0002-0451-4741
Agnieszka Stelmach-GołdyśDepartment of Hematology, Holycross Cancer Center, Kielce, Poland.
Artur KowalikDepartment of Molecular Diagnostics, Holycross Cancer Center, Kielce, Poland.
Stanisław GóźdźDepartment of Immunology, Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland.
Jacek RolińskiDepartment of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.
Holy Cross University · PLJan Kochanowski University · PLMedical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients with monoclonal gammopathy of undetermined significance (MGUS) have an increased risk of developing infections. PATIENTS AND

methodsA total of 22 previously untreated patients with MGUS and 15 healthy age- and sex-matched volunteers were included in the study. All participants were immunized with PCV13 Prevenar13 (Pfizer). The following parameters were assessed: 1) serum-specific pneumococcal antibody titers before and 30 days after vaccination, 2) percentage of plasmablasts, defined as CD19+/IgD-/CD27++, before and 7 days after vaccination, 3) serum total IgG and IgG1, IgG2, IgG3, IgG4 levels before and 30 days after vaccination. RESULTS AND

conclusionPCV13 vaccination in MGUS patients is safe and effectively protects against

Indexed as

AdultCase-Control StudiesFemaleHealthy VolunteersHumansImmunoglobulin GMaleMiddle AgedMonoclonal Gammopathy of Undetermined SignificanceMyeloma ProteinsPneumococcal InfectionsPneumococcal VaccinesVaccines, Conjugate13-valent pneumococcal vaccineImmunoglobulin Gmultiple myeloma M-proteinsMyeloma ProteinsPneumococcal VaccinesVaccines, Conjugate13-valent pneumococcal conjugate vaccineimmune responsemonoclonal gammopathy of undetermined significanceM proteinplasmablastspneumococcal antibodies

Identifiers

PMID31631993
PMCPMC6790629
OpenAlexW2980054548

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.