ArticleClinical interventions in aging2019
The Co-Occurrence Of Frailty (Accumulation Of Functional Deficits) And Depressive Symptoms, And Its Effect On Mortality In Older Adults: A Longitudinal Study.
Article in Clinical interventions in aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Geriatric Assessment as an Important Tool for Post-Hip Surgery Prognosis in Seniors.Nursing reports (Pavia, Italy) · 2025Article
- Joint predictability of physical frailty/pre-frailty and subjective memory complaints on mortality risk among cognitively unimpaired older adults.European journal of ageing · 2023Article
- Association of Proinflammatory Diet With Frailty Onset Among Adults With and Without Depressive Symptoms: Results From the Framingham Offspring Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- The relationship between physical activity trajectories and frailty: a 20-year prospective cohort among community-dwelling older people.BMC geriatrics · 2022Article
- Associations of poor sleep quality, chronic pain and depressive symptoms with frailty in older patients: is there a sex difference?BMC geriatrics · 2022Article
- The influence of multiple frailty profiles on institutionalization and all-cause mortality in community-living older adults.Journal of cachexia, sarcopenia and muscle · 2022Article
- Path Model Factors Associated with Depressive Symptoms among Older Thais Living in Rural Areas.Geriatrics (Basel, Switzerland) · 2022Article
- Do opposite ends of same factors underlie life satisfaction vs. depressive symptoms among older people?Aging clinical and experimental research · 2021Article
- The inter-relationship between depressed mood, functional decline and disability over a 10-year observational period within the Longitudinal Urban Cohort Ageing Study (LUCAS).Journal of epidemiology and community health · 2021Observational
- Frailty in Rheumatic Diseases.Frontiers in immunology · 2020Review
- Malnutrition and Physical Frailty among Nursing Home Residents: A Cross-Sectional Study in China.The journal of nutrition, health & aging · 2020Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe co-occurrence of frailty and depression in late life, the possibility for symptom reversal, their reciprocal relationship, and the effects on mortality have rarely been investigated. We aimed to examine the co-occurrence of frailty and depressive symptoms in late life, the possibility for symptom reversal, their reciprocal relationship, and the effects on mortality using all the information from a longitudinal study. PATIENTS AND
methodsWe used the Taiwan Longitudinal Study of Aging (TLSA) for this study. TLSA was initiated in 1989 and followed periodically. We included participants from 1989 to 2007, who had data on frailty and depressive symptoms. Frailty was assessed by accumulation of functional deficits in 6 dimensions including disease status, sensory dysfunction, balance, functional limitations, health risk behaviors, and life satisfaction. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression Scale (CES-D). A multistate model with interval censoring was used to examine the transition between states of frailty with or without depressive symptoms, and finally to death. A mixed model was used to examine the relationships between frailty and depressive symptoms.
resultsThe coexistence of frailty and depressive symptoms was associated with higher mortality. Individuals with depressive symptom had a lower probability of reversal to a better state. Previous depression score predicted current frailty, but the coefficient was smaller than that of previous frailty. Previous frailty predicted current depression score, and the coefficient was stronger than that of previous depression.
conclusionDepressive symptoms increased the mortality and decreased the probability of reversal in the frail older adults.
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