Evidence map›Paper›PMID 31631985›Full record

ArticlePatient preference and adherence2019

Patient Preferences For Chemotherapy In The Treatment Of Non-Small Cell Lung Cancer: A Multicenter Discrete Choice Experiment (DCE) Study In China.

Hui Sun, Huishan Wang, Ningze Xu, Junling Li, Jufang Shi, Naitong Zhou, Ming Ni, Xianzhi Hu, Yingyao Chen

Open access · goldAbstract read
In one paragraph

Article in Patient preference and adherence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
5.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 1 country.

Hui SunKey Lab of Health Technology Assessment, National Health Commission, School of Public Health, Fudan University, Shanghai, People's Republic of China.
Huishan WangThe Second Clinical Medical School of Nanjing Medical University, Nanjing, People's Republic of China.
Ningze XuKey Lab of Health Technology Assessment, National Health Commission, School of Public Health, Fudan University, Shanghai, People's Republic of China.
Junling LiChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Jufang ShiChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Naitong ZhouWest China School of Pharmacy, Sichuan University, Chengdu, People's Republic of China.
Ming NiFudan University Shanghai Cancer Center, Shanghai, People's Republic of China.
Xianzhi HuSun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China.
Yingyao ChenKey Lab of Health Technology Assessment, National Health Commission, School of Public Health, Fudan University, Shanghai, People's Republic of China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNDevelopment Research Center · CNFudan University · CNFudan University Shanghai Cancer Center · CNNational Health and Family Planning Commission · CNSecond Affiliated Hospital of Nanjing Medical University · CNSichuan University · CNSun Yat-sen University Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study aims to quantify patients' risk-benefit preferences for chemotherapy in the treatment of non-small cell lung cancer (NSCLC), and to elicit their willingness to pay (WTP) for treatment outcomes.

methodsA face-to-face discrete choice experiment (DCE) was conducted on NSCLC patients in four tertiary hospitals each from Beijing, Shanghai, Guangzhou and Chengdu in China. Patients were invited to complete choice questions that constructed by seven attributes: progression-free survival (PFS), disease control rate (DCR), rash, nausea and vomiting, tiredness, mode of administration and out-of-pocket costs. A mixed logit model was used to evaluate the choice model. Estimates of relative preferences and marginal willingness to pay for each attribute were then explored.

resultsA total of 361 patients completed the survey. Improvements in PFS (10, 95% CI: 8.4-11.6) were the most important attribute for patients, followed by increase in DCR (4.6, 95% CI: 3.4-5.8). Tiredness (3.9, 95% CI: 2.9-5.1) was judged to be the most important risk. While remaining attributes were ranked in decreasing order of importance: nausea and vomiting (1.9, 95% CI: 0.9-3.0), mode of administration (0.8, 95% CI: 0.2-1.4) and rash (0.5, 95% CI: -0.6-1.5). There was little variation in preferences among patients with different sociodemographic characteristics. Patients were monthly willing to pay $2304 (95% CI, $1916-$2754) that guaranteed 11 months of PFS, followed by $1465 (95% CI, $1163-$1767) per month to improve their disease control rate by 90%.

conclusionThe results suggested that efficacy was the most important attribute for patients. Side effects, mode of administration and treatment cost significantly influenced patient preferences. Patient engagement in prioritizing their treatment preferences should be emphasized during the clinical decision-making process and regimen implementation.

Indexed as

chemotherapydiscrete choice experimentnon-small cell lung cancerpatient preferences

Identifiers

PMID31631985
PMCPMC6790116
OpenAlexW2979053882

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.