ArticleChemistry of materials : a publication of the American Chemical Society2019
Supramolecular Self-Assembly To Control Structural and Biological Properties of Multicomponent Hydrogels.
Article in Chemistry of materials : a publication of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Supramolecular engineering of fibrinogen into a fibrin matrix with enhanced bioactive properties.Bioactive materials · 2027Article
- Light-triggered modulation in donor-acceptor dipeptide assemblies.Chemical communications (Cambridge, England) · 2026Article
- Molecular-Scale Tuning of Low-Molecular-Weight Gelators Controls Supramolecular Assembly and Directs Human Mesenchymal Stem Cell Growth.Angewandte Chemie (International ed. in English) · 2026Article
- New Properties of Supramolecular Complexes and Drug Nanoparticles.Pharmaceutics · 2026Article
- Controlling Supramolecular Assembly through Peptide Chirality.ACS applied materials & interfaces · 2025Article
- Translational Dynamics and Structural Enhancement Effect in High-Temperature Supramolecular Systems of Asparaginyl Low-Molecular-Weight Gelators and Propylene Carbonate.Macromolecules · 2025Article
- Spiers Memorial Lecture: Recent advances (and challenges) in supramolecular gels.Faraday discussions · 2025Article
- Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix's Complexity.ACS nano · 2025Review
- A Comparison of the Mechanical Properties of ECM Components and Synthetic Self-Assembling Peptides.Advanced healthcare materials · 2025Review
- Understanding multicomponent low molecular weight gels from gelators to networks.Journal of advanced research · 2025Review
- Nanoengineered Self-Assembling Peptides with Increased Proteolytic Stability Promote Wound Healing.ACS applied materials & interfaces · 2025Article
- Biocooperative Regenerative Materials by Harnessing Blood-Clotting and Peptide Self-Assembly.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- New Supramolecular Hydrogels Based on Diastereomeric Dehydrotripeptide Mixtures for Potential Drug Delivery Applications.Gels (Basel, Switzerland) · 2024Article
- Supramolecular Polymer Co-Assembled Multifunctional Chiral Hybrid Hydrogels with Adhesive, Self-Healing and Antibacterial Properties.Gels (Basel, Switzerland) · 2024Article
- Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel-Cell Interactions.Journal of the American Chemical Society · 2024Review
- A Self-Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer.Advanced healthcare materials · 2024Article
- Biofabrication methods for reconstructing extracellular matrix mimetics.Bioactive materials · 2024Review
- Gelation Behaviour of Pluronic F127/Polysaccharide Systems Revealed via Thioflavin T Fluorescence.Gels (Basel, Switzerland) · 2023Article
- Transparent Organogels as a Medium for the Light-Induced Conversion from Spiropyran to Merocyanine.Gels (Basel, Switzerland) · 2023Article
- 3D Printing of Extracellular Matrix-Based Multicomponent, All-Natural, Highly Elastic, and Functional Materials toward Vascular Tissue Engineering.Advanced healthcare materials · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-assembled nanofibers are ubiquitous in nature and serve as inspiration for the design of supramolecular hydrogels. A multicomponent approach offers the possibility of enhancing the tunability and functionality of this class of materials. We report on the synergistic multicomponent self-assembly involving a peptide amphiphile (PA) and a 1,3:2,4-dibenzylidene-d-sorbitol (DBS) gelator to generate hydrogels with tunable nanoscale morphology, improved stiffness, enhanced self-healing, and stability to enzymatic degradation. Using induced circular dichroism of Thioflavin T (ThT), electron microscopy, small-angle neutron scattering, and molecular dynamics approaches, we confirm that the PA undergoes self-sorting, while the DBS gelator acts as an additive modifier for the PA nanofibers. The supramolecular interactions between the PA and DBS gelators result in improved bulk properties and cytocompatibility of the two-component hydrogels as compared to those of the single-component systems. The tunable mechanical properties, self-healing ability, resistance to proteolysis, and biocompatibility of the hydrogels suggest future opportunities for the hydrogels as scaffolds for tissue engineering and drug delivery vehicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.