ReviewAustralian prescriber2019
How to adjust drug doses in chronic kidney disease.
Review in Australian prescriber, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Examining commonly used equations for estimating the glomerular filtration rate (GFR) in a healthy cohort of children and adolescents.BMC nephrology · 2026Observational
- Evaluation of Beers Criteria Implementation in the Community Pharmacy Setting to Optimize Medication Management for Older Adults-A Pilot Study.Geriatrics (Basel, Switzerland) · 2026Article
- Performance of Estimated Kidney Function Equations for Predicting Aminoglycosides Clearance in Thai Population.Journal of clinical pharmacology · 2026Article
- Evaluation of an educational program for community pharmacists involved in pharmacotherapy for patients with impaired renal function: a preliminary study.Clinical and experimental nephrology · 2025Article
- Integrating International Consensus Guidelines for Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) into everyday practice.EClinicalMedicine · 2025Review
- Review
- Renal Impairment and Dose Adjustment of Long-Acting Injectable Antipsychotics: Are We Getting It Right? A Case Report.Focus (American Psychiatric Publishing) · 2024Article
- Best-Practice Perspectives on Improving Early Detection and Management of Chronic Kidney Disease Associated With Type 2 Diabetes in Primary Care.Clinical diabetes : a publication of the American Diabetes Association · 2024Article
- Prescribing and peritoneal dialysis.Australian prescriber · 2023Review
- Evaluation of medication dose adjustments in patients with impaired renal function using different online drug information databases.European journal of hospital pharmacy : science and practice · 2022Observational
- Pharmacokinetics and Bioequivalence of Two Empagliflozin, with Evaluation in Healthy Jordanian Subjects under Fasting and Fed Conditions.Pharmaceuticals (Basel, Switzerland) · 2022Article
- A focus on CKD reporting and inappropriate prescribing among older patients discharged from geriatric and nephrology units throughout Italy: A nationwide multicenter retrospective cross-sectional study.Frontiers in pharmacology · 2022Article
- The Mechanism of Drug Nephrotoxicity and the Methods for Preventing Kidney Damage.International journal of molecular sciences · 2021Review
- Estimating renal function for patients in wheelchairs.Australian prescriber · 2020Article
- Clinical significance of serum cystatin C in early evaluation of renal impairment caused by chemotherapy in elderly patients.Translational cancer research · 2020Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drugs excreted by the kidney require dose reduction in chronic kidney disease. This adjustment depends on the severity of the disease and what proportion of the drug is eliminated by the kidneys The estimated glomerular filtration rate can generally be used to guide dose adjustment in patients with stable kidney function. However, the formula can be misleading in some patient subsets and other approaches are required At extremes of body mass, the estimated glomerular filtration rate can under- or overestimate kidney function. It may need to be adjusted for body surface area, particularly for drugs with a narrow therapeutic range or requiring a minimum concentration to be effective. Close monitoring of drug effect and toxicity is also needed and can be supported by therapeutic drug monitoring For short courses of drugs with a wide therapeutic index, dose adjustment may not be needed Alternative methods for quantifying kidney function include the Cockcroft-Gault formula (estimates creatinine clearance) or direct measures of glomerular filtration rate using exogenous isotope compounds. These are not commonly required
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.