Evidence map›Paper›PMID 31631580›Full record

ArticleThoracic cancer2019

Nevirapine inhibits migration and invasion in dedifferentiated thyroid cancer cells.

Hongxia Shang, Junyu Zhao, Jinming Yao, Huanjun Wang, Shengnan Wang, Jianjun Dong, Lin Liao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hongxia ShangDivision of Endocrinology, Department of Internal Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
Junyu ZhaoDivision of Endocrinology, Department of Internal Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
Jinming YaoDivision of Endocrinology, Department of Internal Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
Huanjun WangDivision of Endocrinology, Department of Internal Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
Shengnan WangDivision of Endocrinology, Department of Internal Medicine, Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University, Jinan, China.
Jianjun DongDivision of Endocrinology, Department of Internal Medicine, Qilu Hospital of Shandong University, Jinan, China.
Lin LiaoDivision of Endocrinology, Department of Internal Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.ORCID 0000-0002-0278-4879
Shandong Provincial QianFoShan Hospital · CNQilu Hospital of Shandong University · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetastatic or recurrent thyroid cancer often behaves aggressively, and approximately two-thirds of patients present with radioiodine resistance. Effective therapies to suppress thyroid cancer metastasis are urgently needed. Nevirapine has been proved to suppress tumor growth and induce differentiation in several tumor cells, but has not previously been evaluated in metastasis of thyroid cancer. The present study aimed to investigate the effect of nevirapine on migration and invasion in dedifferentiated thyroid cancer cells.

methodsHuman dedifferentiated thyroid cancer cell line (WRO 82-1) was subject to real-time quantitative PCR, western blot and transwell migration/invasion assays. The liver metastasis in tumor xenografts of nude mice was subject to hematoxylin-eosin (HE) staining.

resultsNevirapine significantly repressed cell migration and invasion in WRO 82-1 cells, and surprisingly significantly decreased liver metastatic tumor in the nude mouse model of dedifferentiated thyroid cancer compared with that of the control. Moreover, nevirapine significantly decreased the expression of IL-6 mRNA and phosphorylation of JAK2 (Y1007+Y1008) and STAT3 (Tyr 705) in WRO 82-1 cells compared with those in control cells.

conclusionOur findings suggest that nevirapine significantly repressed migration and invasion/metastasis in WRO 82-1 cells and tumor xenografts, which may be related to inhibition of IL-6/STAT3 signaling pathway. It promises great potential as a novel therapy for thyroid cancer, especially for those patients with metastasis.

Indexed as

AnimalsAntineoplastic AgentsApoptosisBiopsyCell Line, TumorCell MovementCell ProliferationDisease Models, AnimalHumansImmunohistochemistryInterleukin-6Liver NeoplasmsMiceNevirapineSignal TransductionSTAT3 Transcription FactorAntineoplastic AgentsInterleukin-6NevirapineSTAT3 protein, humanSTAT3 Transcription FactorDedifferentiated thyroid cancerIL-6/STAT3 signaling pathwayinvasionmigrationnevirapine

Identifiers

PMID31631580
PMCPMC6885442
OpenAlexW2981061830

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.