Evidence map›Paper›PMID 31631339›Full record

ArticleImmunology2020

Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation.

Janina M Kuehlwein, Max Borsche, Patricia J Korir, Frederic Risch, Ann-Kristin Mueller, Marc P Hübner, Kai Hildner, Achim Hoerauf, Ildiko Rita Dunay, Beatrix Schumak

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Inhibition ofBiomedicines · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Janina M KuehlweinInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0003-3648-2649
Max BorscheInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
Patricia J KorirInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
Frederic RischInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
Ann-Kristin MuellerParasitology Unit, Centre for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
Marc P HübnerInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0001-8885-418X
Kai HildnerMedical Department 1, University Hospital Erlangen, Erlangen, Germany.
Achim HoeraufInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
Ildiko Rita DunayInstitute of Inflammation and Neurodegeneration, University of Magdeburg, Magdeburg, Germany.
Beatrix SchumakInstitute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0003-0749-3170
University Hospital Bonn · DEHeidelberg University · DEUniversitätsklinikum Erlangen · DEUniversity Hospital Magdeburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive inflammatory immune responses during infections with Plasmodium parasites are responsible for severe complications such as cerebral malaria (CM) that can be studied experimentally in mice. Dendritic cells (DCs) activate cytotoxic CD8

Indexed as

AnimalsBasic-Leucine Zipper Transcription FactorsBlood-Brain BarrierBrainCells, CulturedDendritic CellsDisease Models, AnimalFemaleGranzymesHost-Parasite InteractionsInterferon-gammaInterleukin-10Malaria, CerebralMice, Inbred C57BLMice, KnockoutPlasmodium bergheiBasic-Leucine Zipper Transcription FactorsGranzymesGzmb protein, mouseIFNG protein, mouseIL10 protein, mouseInterferon-gammaInterleukin-10Repressor ProteinsSNFT protein, mousedendritic cellsexperimental cerebral malariainflammationPlasmodiumT-cells

Identifiers

PMID31631339
PMCPMC6954726
OpenAlexW2981642747

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.