ArticleStem cell reports2019
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
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Article in Stem cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
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Who cites it
65 citing papers in PubMed, 120 citations in OpenAlex.
- Simulated microgravity induces aging phenotypes in human organoids.bioRxiv : the preprint server for biology · 2026Article
- Large-scale single-molecule analysis of tau proteoforms.Nature methods · 2026Article
- Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau.Science advances · 2026Article
- tRNA-derived fragments elevated in Alzheimer's disease promote Tau aggregation.bioRxiv : the preprint server for biology · 2026Article
- ThebioRxiv : the preprint server for biology · 2026Article
- Patient-derived forebrain cortical organoids reveal biphasic tau-MAP6-microtubule axis dysfunction in tauopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects.Cell · 2026Article
- Article
- A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia.Nature communications · 2026Article
- Multi-omic phenotyping of MAPT V337M neurons reveals early changes in axonogenesis and tau phosphorylation.NPJ dementia · 2026Article
- Replicable generation and stable maintenance of rhesus macaque iPSCs forFrontiers in cell and developmental biology · 2026Article
- Mitochondrial Transplantation Increases Bioenergetics and Neurite Outgrowth in Healthy and P301Ltau-Expressing SH-SY5Y Cells.Molecular neurobiology · 2025Article
- A novel lncRNA FAM151B-DT regulates degradation of aggregation prone proteins.Molecular psychiatry · 2025Article
- A Model of Traumatic Brain Injury Oligomerizes Tau in Cortical Organoids and Induces Clinically Relevant Pathologies that Synergize withJournal of neurotrauma · 2025Article
- Mutant MAPT Induces rDNA Transcriptional Hyperactivation and Nucleolar Stress in Cellular Models.Research square · 2025Article
- Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau.Molecular psychiatry · 2025Article
- Cortical versus hippocampal network dysfunction in a human brain assembloid model of epilepsy and intellectual disability.Cell reports · 2025Article
- Multi-omic phenotyping of iPSC-derived neurons harboring thebioRxiv : the preprint server for biology · 2025Article
- Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction.Nature metabolism · 2025Article
- Modeling Sporadic Progressive Supranuclear Palsy in 3D Midbrain Organoids: Recapitulating Disease Features for In Vitro Diagnosis and Drug Discovery.Annals of neurology · 2025Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
35 authors at 10 institutions in 1 country.
Celeste M KarchDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 425 South Euclid Avenue, Campus Box 8134, St. Louis, MO 63110, USA. Electronic address: karchc@wustl.edu.
Aimee W KaoDivision of Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Anna KarydasDivision of Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Khadijah OnanugaNeural Stem Cell Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA.
Rita MartinezDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 425 South Euclid Avenue, Campus Box 8134, St. Louis, MO 63110, USA.
Andrea ArgouarchDivision of Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Chao WangGladstone Institutes of Neurological Disease, Department of Neurology, Neuroscience Graduate Program, University of California, San Francisco, CA 94158, USA.
Cindy HuangGladstone Institutes of Neurological Disease, Department of Neurology, Neuroscience Graduate Program, University of California, San Francisco, CA 94158, USA.
Peter Dongmin SohnGladstone Institutes of Neurological Disease, Department of Neurology, Neuroscience Graduate Program, University of California, San Francisco, CA 94158, USA.
Kathryn R BowlesRonald M. Loeb Center for Alzheimer's Disease, Departments of Neuroscience, Neurology and Genetics & Genomic Sciences, Icahn School of Medicine, New York, NY 10029, USA.
Salvatore SpinaDivision of Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
M Catarina SilvaChemical Neurobiology Laboratory, Center for Genomic Medicine, Departments of Neurology & Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Jacob A MarshDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 425 South Euclid Avenue, Campus Box 8134, St. Louis, MO 63110, USA.
Simon HsuDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 425 South Euclid Avenue, Campus Box 8134, St. Louis, MO 63110, USA.
Derian A PughRonald M. Loeb Center for Alzheimer's Disease, Departments of Neuroscience, Neurology and Genetics & Genomic Sciences, Icahn School of Medicine, New York, NY 10029, USA.
Nupur GhoshalDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.
Joanne NortonDepartment of Psychiatry, Washington University in St. Louis School of Medicine, 425 South Euclid Avenue, Campus Box 8134, St. Louis, MO 63110, USA.
Yadong HuangGladstone Institutes of Neurological Disease, Department of Neurology, Neuroscience Graduate Program, University of California, San Francisco, CA 94158, USA.
Suzee E LeeDivision of Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
William W SeeleyDivision of Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Panagiotis TheofilasDepartment of Pathology and Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Lea T GrinbergDepartment of Pathology and Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Fermin MorenoDivision of Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Kathryn McIlroyNeural Stem Cell Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Nigel J CairnsDepartment of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA.
John F CraryRonald M. Loeb Center for Alzheimer's Disease, Departments of Neuroscience, Neurology and Genetics & Genomic Sciences, Icahn School of Medicine, New York, NY 10029, USA; Department of Pathology, Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Stephen J HaggartyChemical Neurobiology Laboratory, Center for Genomic Medicine, Departments of Neurology & Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Justin K IchidaDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Kenneth S KosikDepartment of Molecular Cellular and Developmental Biology, Neuroscience Research Institute, Biomolecular Science and Engineering Program, University of California, Santa Barbara, Santa Barbara, CA, USA.
Bruce L MillerDivision of Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Li GanGladstone Institutes of Neurological Disease, Department of Neurology, Neuroscience Graduate Program, University of California, San Francisco, CA 94158, USA.
Alison M GoateRonald M. Loeb Center for Alzheimer's Disease, Departments of Neuroscience, Neurology and Genetics & Genomic Sciences, Icahn School of Medicine, New York, NY 10029, USA.
Sally TempleNeural Stem Cell Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA. Electronic address: sallytemple@neuralsci.org.
Tau Consortium Stem Cell Group
University of California, San Francisco · USWashington University in St. Louis · USGladstone Institutes · USNeural Stem Cell Institute · USHarvard University · USUniversity of California, Santa Barbara · USUniversity of Southern California · USAllen Institute for Brain Science · USMayo Clinic · USQB3 · US
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI CHENGJIE XIONG · 1985 to 2026
$69.5MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI FAGAN, ANNE · 1985 to 2019
$52.1MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9MResearch Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7MPrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MMultidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4MINTERDISCIPLINARY RESEARCH CAREERS IN WOMEN'S HEALTHK12HD001459 · NICHD · WASHINGTON UNIVERSITY · PI SEMENKOVICH, CLAY F. · 2000 to 2014
$6.9MTraining - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4MDefining Characteristics of Cortical Progenitor Cells over Time in Mouse and HumanR35NS097277 · NINDS · REGENERATIVE RESEARCH FOUNDATION · PI TEMPLE, SALLY · 2017 to 2024
$5.0MNIA NIH HHS K01 AG046374NIA NIH HHS K08 AG052648NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG066444NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG051390NIA NIH HHS R01 AG054008NIA NIH HHS R01 AG056293NIA NIH HHS R01 AG058233NIA NIH HHS T32 AG023481NIA NIH HHS U01 AG045390NIA NIH HHS U24 AG021886NICHD NIH HHS K12 HD001459NINDS NIH HHS R01 NS095252NINDS NIH HHS R35 NS097277NINDS NIH HHS U54 NS092089
Abstract
Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal dominant mutations in the MAPT gene cause heterogeneous forms of frontotemporal lobar degeneration with tauopathy (FTLD-Tau). Common and rare variants in the MAPT gene increase the risk for sporadic FTLD-Tau, including progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We generated a collection of fibroblasts from 140 MAPT mutation/risk variant carriers, PSP, CBD, and cognitively normal controls; 31 induced pluripotent stem cell (iPSC) lines from MAPT mutation carriers, non-carrier family members, and autopsy-confirmed PSP patients; 33 genome engineered iPSCs that were corrected or mutagenized; and forebrain neural progenitor cells (NPCs). Here, we present a resource of fibroblasts, iPSCs, and NPCs with comprehensive clinical histories that can be accessed by the scientific community for disease modeling and development of novel therapeutics for tauopathies.
Indexed as
Cell LineFibroblastsGene EditingHumansInduced Pluripotent Stem CellsMutationNeural Stem CellsNeurogenesisNeuronsTauopathiestau ProteinsMAPT protein, humantau Proteinscorticobasal degenerationCRISPR/Cas9fibroblastsfrontotemporal dementiainduced pluripotent stem cellsMAPTneural progenitor cellsprogressive supranuclear palsytautauopathy
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