ArticleNeuron2019
TREK-1 and TRAAK Are Principal K
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
82 citing papers in PubMed, 136 citations in OpenAlex.
- Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- One pocket to activate them all (?): Efforts on understanding the modulator pocket in K2P channels.Channels (Austin, Tex.) · 2026Review
- Cancer pain.Nature reviews. Disease primers · 2026Review
- K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses.Frontiers in pharmacology · 2026Review
- Review
- Cytoskeletal scaffolding of NaCurrent opinion in cell biology · 2025Review
- Structure of the human KNature structural & molecular biology · 2025Article
- Article
- Axon initial segment structure and function in health and disease.Physiological reviews · 2025Review
- Restore axonal conductance in a locally demyelinated axon with electromagnetic stimulation.Journal of neural engineering · 2025Article
- Potassium channel clustering: mechanisms shaping axonal excitability.Frontiers in cellular neuroscience · 2025Review
- Article
- Physiology of Oligodendroglia.Advances in neurobiology · 2025Review
- Multimodal Characterization of Cortical Neuron Response to Permanent Magnetic Field Induced Nanomagnetic Force Maps.ACS nano · 2024Article
- Cannabinoid inhibition of mechanosensitive KbioRxiv : the preprint server for biology · 2024Article
- In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons.Nature communications · 2024Article
- An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels.The Journal of cell biology · 2024Article
- Development of a 3-dimensional organotypic model with characteristics of peripheral sensory nerves.Cell reports methods · 2024Article
- An ankyrin G-binding motif mediates TRAAK periodic localization at axon initial segments of hippocampal pyramidal neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Development of covalent chemogenetic KCell chemical biology · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Rapid conduction of nerve impulses is critical in life and relies on action potential (AP) leaps through the nodes of Ranvier (NRs) along myelinated nerves. While NRs are the only sites where APs can be regenerated during nerve conduction on myelinated nerves, ion channel mechanisms underlying the regeneration and conduction of APs at mammalian NRs remain incompletely understood. Here, we show that TREK-1 and TRAAK, the thermosensitive and mechanosensitive two-pore-domain potassium (K2P) channels, are clustered at NRs of rat trigeminal Aβ-afferent nerves with a density over 3,000-fold higher than that on their somas. These K2P channels, but not voltage-gated K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.