Evidence map›Paper›PMID 31630868›Full record

ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2019

Synthetic MRI-aided multi-organ segmentation on male pelvic CT using cycle consistent deep attention network.

Xue Dong, Yang Lei, Sibo Tian, Tonghe Wang, Pretesh Patel, Walter J Curran, Ashesh B Jani, Tian Liu, Xiaofeng Yang

Open access · greenAbstract read
In one paragraph

Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Deep learning in MRI-guided radiation therapy: A systematic review.Journal of applied clinical medical physics · 2024
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  6. A review of artificial intelligence in brachytherapy.Journal of applied clinical medical physics · 2025
    Review
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  10. Achieving accurate prostate auto-segmentation on CT in the absence of MR imaging.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xue DongDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, GA, United States.
Yang LeiDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, GA, United States.
Sibo TianDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, GA, United States.
Tonghe WangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, GA, United States.
Pretesh PatelDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, GA, United States.
Walter J CurranDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, GA, United States.
Ashesh B JaniDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, GA, United States.
Tian LiuDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, GA, United States.
Xiaofeng YangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, GA, United States. Electronic address: xiaofeng.yang@emory.edu.
Emory University · US

Funding

Multiparametric MRI-guided Prostate HDR Brachytherapy with Focal Tumor BoostR01CA215718 · NCI · EMORY UNIVERSITY · PI YANG, XIAOFENG · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA215718
6 · The paper itself

Abstract

background and purposeManual contouring is labor intensive, and subject to variations in operator knowledge, experience and technique. This work aims to develop an automated computed tomography (CT) multi-organ segmentation method for prostate cancer treatment planning. METHODS AND MATERIALS: The proposed method exploits the superior soft-tissue information provided by synthetic MRI (sMRI) to aid the multi-organ segmentation on pelvic CT images. A cycle generative adversarial network (CycleGAN) was used to estimate sMRIs from CT images. A deep attention U-Net (DAUnet) was trained on sMRI and corresponding multi-organ contours for auto-segmentation. The deep attention strategy was introduced to identify the most relevant features to differentiate different organs. Deep supervision was incorporated into the DAUnet to enhance the features' discriminative ability. Segmented contours of a patient were obtained by feeding CT image into the trained CycleGAN to generate sMRI, which was then fed to the trained DAUnet to generate organ contours. We trained and evaluated our model with 140 datasets from prostate patients.

resultsThe Dice similarity coefficient and mean surface distance between our segmented and bladder, prostate, and rectum manual contours were 0.95 ± 0.03, 0.52 ± 0.22 mm; 0.87 ± 0.04, 0.93 ± 0.51 mm; and 0.89 ± 0.04, 0.92 ± 1.03 mm, respectively.

conclusionWe proposed a sMRI-aided multi-organ automatic segmentation method on pelvic CT images. By integrating deep attention and deep supervision strategy, the proposed network provides accurate and consistent prostate, bladder and rectum segmentation, and has the potential to facilitate routine prostate-cancer radiotherapy treatment planning.

Indexed as

Deep LearningHumansMagnetic Resonance ImagingMaleOrgans at RiskPelvisProstatic NeoplasmsTomography, X-Ray ComputedDeep learningMulti-organ segmentationSynthetic MRI

Identifiers

PMID31630868
PMCPMC6899191
OpenAlexW2980323948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.