Evidence map›Paper›PMID 31630675›Full record

ArticleMolecular brain2019

Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli.

Alexandra Bunda, Brianna LaCarubba, Melanie Bertolino, Marie Akiki, Kevin Bath, Javier Lopez-Soto, Diane Lipscombe, Arturo Andrade

Open access · goldAbstract read
In one paragraph

Article in Molecular brain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Rbfox1 regulates alternative splicing of Nrcam in primary sensory neurons to mediate peripheral nerve injury-induced neuropathic pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alexandra BundaDepartment of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
Brianna LaCarubbaDepartment of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
Melanie BertolinoDepartment of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
Marie AkikiDepartment of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
Kevin BathDepartment of Cognitive, Linguistic and Psychological Sciences, Brown University, 190 Thayer Street, Providence, RI, 02912, USA.
Javier Lopez-SotoRobert J and Nancy D Carney Institute for Brain Science & Department of Neuroscience, Brown University, 185 Meeting Street, Providence, RI, 02912, USA.
Diane LipscombeRobert J and Nancy D Carney Institute for Brain Science & Department of Neuroscience, Brown University, 185 Meeting Street, Providence, RI, 02912, USA.
Arturo AndradeDepartment of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA. Arturo.Andrade@unh.edu.ORCID 0000-0001-6585-2413
University of New Hampshire · USAllen Institute for Brain Science · USBrown University · US

Funding

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI Sean Stoddart Coleman Edington · 2017 to 2026
$22.8M
Voltage-Gated Calcium Channels in Nociceptors and MechanoreceptorsR01NS055251 · NINDS · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE · 2006 to 2025
$9.1M
Mechanisms driving sex differences in cognitive outcomes following early life stressR01MH115049 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BATH, KEVIN GEORGE · 2018 to 2022
$2.7M
Early Life Stress Effects on Threat LearningR01MH115914 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BATH, KEVIN GEORGE · 2018 to 2022
$2.2M
Role of Gi/o-Protein Inhibition of CaV2.2 Channels in Anxiety BehaviorR00MH099405 · NIMH · UNIVERSITY OF NEW HAMPSHIRE · PI ANDRADE, ARTURO · 2015 to 2017
$738k
Role of Gi/o-Protein Inhibition of CaV2.2 Channels in Anxiety BehaviorK99MH099405 · NIMH · BROWN UNIVERSITY · PI ANDRADE, ARTURO · 2013 to 2014
$180k
NIGMS NIH HHS P20 GM113131NIMH NIH HHS K99 MH099405NIMH NIH HHS R00 MH099405NIMH NIH HHS R01 MH115049NIMH NIH HHS R01 MH115914NINDS NIH HHS R01 NS055251
6 · The paper itself

Abstract

Presynaptic Ca

Indexed as

Behavior, AnimalAlternative SplicingAnimalsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium Channels, N-TypeFemaleGene Expression RegulationMaleMice, Inbred C57BLMice, TransgenicNeuronsPhysical StimulationProtein IsoformsRNA, MessengerSynapsesCacna1b protein, mouseCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium Channels, N-TypeProtein IsoformsRNA, MessengerAlternative splicingAnxietyCalcium channelsCaV2.2 channelsDentate gyrusExploratory behaviorMedial entorhinal cortexMedial perforant path

Identifiers

PMID31630675
PMCPMC6802325
OpenAlexW2980511836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.