Evidence map›Paper›PMID 31630572›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

Chronic Elevation of Endothelin-1 Alone May Not Be Sufficient to Impair Endothelium-Dependent Relaxation.

Zachary I Grunewald, Thomas J Jurrissen, Makenzie L Woodford, Francisco I Ramirez-Perez, Lauren K Park, Ryan Pettit-Mee, Thaysa Ghiarone, Scott M Brown, Mariana Morales-Quinones, James R Ball and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Endothelial HSP72 is not reduced in type 2 diabetes nor is it a key determinant of endothelial insulin sensitivity.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  2. Article
  3. Hyperinsulinemia blunts sympathetic vasoconstriction: a possible role of β-adrenergic activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Zachary I GrunewaldFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
Thomas J JurrissenFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
Makenzie L WoodfordFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
Francisco I Ramirez-PerezDalton Cardiovascular Research Center (Z.I.G., T.J.J., M.L.W., F.I.R.-P., L.K.P., R.P.-M., T.G., M.M.-Q., S.B.B., L.A.M.-L., J.P.), University of Missouri, Columbia.
Lauren K ParkFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
Ryan Pettit-MeeFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
Thaysa GhiaroneFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
Scott M BrownDepartment of Biomedical Sciences (S.M.B., S.B.B.), University of Missouri, Columbia.
Mariana Morales-QuinonesFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
James R BallFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
Kevin F Staveley-O'CarrollDepartment of Surgery (K.F.S.-O.), University of Missouri, Columbia.
Annayya R AroorHarry S. Truman Memorial Veterans Hospital (S.M.B., A.R.A., S.B.B.), University of Missouri, Columbia.
Paul J FadelDepartment of Kinesiology, University of Texas at Arlington (P.J.F.).
Pierre ParadisHypertension and Vascular Research Unit, Lady Davis Institute for Medical Research (P.P., E.L.S.), McGill University, Montreal, Québec, Canada.
Ernesto L SchiffrinHypertension and Vascular Research Unit, Lady Davis Institute for Medical Research (P.P., E.L.S.), McGill University, Montreal, Québec, Canada.
Shawn B BenderFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
Luis A Martinez-LemusFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
Jaume PadillaFrom the Department of Nutrition and Exercise Physiology (Z.I.G., T.J.J., M.L.W., L.K.P., R.P.-M., J.R.B., J.P.), University of Missouri, Columbia.
University of Missouri · USHarry S. Truman Memorial Veterans' Hospital · USThe University of Texas at Arlington · US

Funding

MINORITY BIOMEDICAL RESEARCHERS TRAINING INITIATIVER25GM056901 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI HANNINK, MARK · 1999 to 2019
$8.4M
Mechanisms of Microvascular Remodeling ProgressionR01HL088105 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MARTINEZ-LEMUS, LUIS A · 2009 to 2019
$3.3M
Mineralocorticoid receptor-dependent coronary vascular dysfunction in obesityR01HL136386 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI BENDER, SHAWN BRADY · 2018 to 2022
$2.8M
Restoring vasodilator actions of insulin in patients with type 2 diabetesR01HL137769 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PADILLA, JAUME · 2017 to 2021
$2.5M
Targeting Sympathetic Overactivity in CKD patients: Mechanisms & Novel TherapiesR01HL127071 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI FADEL, PAUL J · 2016 to 2019
$1.7M
Vascular Insulin Resistance in Obesity: Role of Endoplasmic Reticulum StressK01HL125503 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PADILLA, JAUME · 2015 to 2018
$564k
CIHR 143348NHLBI NIH HHS K01 HL125503NHLBI NIH HHS R01 HL088105NHLBI NIH HHS R01 HL127071NHLBI NIH HHS R01 HL136386NHLBI NIH HHS R01 HL137769NIGMS NIH HHS R25 GM056901
6 · The paper itself

Abstract

Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide considered to be causally implicated in hypertension and the development of cardiovascular disease. Increased ET-1 is commonly associated with reduced NO bioavailability and impaired vascular function; however, whether chronic elevation of ET-1 directly impairs endothelium-dependent relaxation (EDR) remains elusive. Herein, we report that (1) prolonged ET-1 exposure (ie, 48 hours) of naive mouse aortas or cultured endothelial cells did not impair EDR or reduce eNOS (endothelial NO synthase) activity, respectively (

Indexed as

AnimalsAortaBlotting, WesternEndothelial CellsEndothelin-1FemaleIn Vitro TechniquesMass SpectrometryMiceMice, Inbred C57BLModels, AnimalNitric OxideSensitivity and SpecificityVasoconstrictor AgentsVasodilationEndothelin-1Nitric OxideVasoconstrictor Agentsaortablood pressurehumanshypertensionNO synthase

Identifiers

PMID31630572
PMCPMC6854321
OpenAlexW2980828857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.