ArticleJournal of clinical laboratory analysis2020
Comparison of serum Lp-PLA2 levels in ischemic stroke patients with H-type hypertension or non-H-type hypertension.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Diagnostic Utility of Combining Homocysteine, Lipoprotein-Associated Phospholipase A2, and the C-Reactive Protein-to-Albumin Ratio for Assessing Carotid Atherosclerosis and Plaque Stability in Patients with Essential Hypertension.Cardiovascular toxicology · 2025Article
- Severity and Prognosis of Vascular Dementia in Patients with Acute Cerebral Infarction Combined with H-Type Hypertension and Its Correlation with Uric Acid Levels.Neuropsychiatric disease and treatment · 2025Article
- Repetitive Transcranial Magnetic Stimulation Combined with Ginkgo Diterpene Lactone Meglumine Injection Recover Cognitive and Neurological Functions of Patients with Acute Ischemic Stroke.Actas espanolas de psiquiatria · 2025Article
- Internal mechanism of correlation between angiotensin II gene and serum adiponectin level in patients with cerebrovascular complications of H-type hypertension.Journal of medical biochemistry · 2024Article
- Lipid-Derived Biomarkers as Therapeutic Targets for Chronic Coronary Syndrome and Ischemic Stroke: An Updated Narrative Review.Medicina (Kaunas, Lithuania) · 2024Review
- Negative correlation between early recovery and lipoprotein-associated phospholipase A2 levels after intravenous thrombolysis.The Journal of international medical research · 2022Article
- Correlation of Blood Lipid and Serum Inflammatory Factor Levels With Hypertensive Disorder Complicating Pregnancy.Frontiers in surgery · 2022Article
- Prognostic value of color Doppler ultrasound, D-dimer, and Lp-PLA2 levels in carotid atherosclerotic stenosis.American journal of translational research · 2021Article
- Lipoprotein-Associated Phospholipase A2 Is a Risk Factor for Patients With Parkinson's Disease.Frontiers in neuroscience · 2021Article
- Comparison of serum Lp-PLA2 levels in ischemic stroke patients with H-type hypertension or non-H-type hypertension.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIncreased serum Lp-PLA2 levels have been reported in patients who experienced an ischemic stroke; however, the relationship between Lp-PLA2 and H-type hypertension in patients with ischemic stroke remains unclear.
methodsIn the present study, we investigated the correlation between serum Lp-PLA2 and H-type hypertension in patients with ischemic stroke. A total of 135 patients who experienced acute ischemic stroke were enrolled in Tianjin Huanhu Hospital during October 2015 to May 2016. The demographic characteristics of the patients were collected, and biochemical parameters were detected.
resultsAmong the 135 patients, 111 patients had essential hypertension, including 41 patients with H-type hypertension and 70 with non-H-type hypertension. There were higher proportions of males and patients with diabetes mellitus in the H-type hypertension group compared with the non-H-type hypertension group (P < .05). Lp-PLA2, glucose, and LDL-C levels were higher in the H-type hypertension group than in the non-H-type hypertension group (P < .05). Multivariate logistic regression showed that Lp-PLA2 levels >208.46 mg/L were independently associated with H-type hypertension in patients with ischemic stroke (OR: 2.560, 95% CI: 1.085-6.040, P = .032). The area under the ROC curve of Lp-PAL2 levels in the H-type hypertension group was 0.665 (95% CI: 0.561-0.768, P = .004).
conclusionSynergetic effects of H-type hypertension and Lp-PLA2 levels were noted in the pathogenesis of ischemic stroke.
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