ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2020
Comparison of adsorption of selected antibiotics on the filters in continuous renal replacement therapy circuits: in vitro studies.
Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Impact of adsorptive CRRT membranes on vancomycin pharmacokinetics in critically ill patients.Renal failure · 2026Review
- The impact of an ex vivo paediatric renal replacement therapy circuit on antimicrobial concentrations.The Journal of antimicrobial chemotherapy · 2026Article
- Population Pharmacokinetics of Vancomycin in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy: Influence of Adsorptive Membranes.Clinical and translational science · 2026Article
- Clearance of Amlodipine, Fentanyl, Fluconazole, Methylprednisolone, and Midazolam by Continuous Renal Replacement Circuits.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025Article
- Amiodarone extraction by continuous renal replacement therapy: results from an ex vivo study.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Haemoadsorption to remove inflammatory mediators in sepsis: past, present, and future.Intensive care medicine experimental · 2025Review
- Interaction of milrinone with extracorporeal life support.The journal of extra-corporeal technology · 2024Article
- CRRT Is More Than Just Continuous Renal Replacement Therapy.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Edoxaban pharmacokinetics during in vitro continuous renal replacement therapy.BMC nephrology · 2024Article
- Focusing on the Basic Principles of Dialysis to Optimize Antibiotic Therapy during Renal Replacement Therapy in Critically Ill Patients.Antibiotics (Basel, Switzerland) · 2024Article
- Different distances between central venous catheter tips can affect antibiotic clearance during continuous renal replacement therapy.Intensive care medicine experimental · 2024Article
- Population Pharmacokinetics of Tigecycline for Critically Ill Patients Undergoing Continuous Renal Replacement Therapy.Drug design, development and therapy · 2024Article
- Anakinra Removal by Continuous Renal Replacement Therapy: An Ex Vivo Analysis.Critical care explorations · 2023Article
- Vancomycin Sequestration in ST Filters: An In Vitro Study.Antibiotics (Basel, Switzerland) · 2023Article
- Antimicrobial Exposure in Critically Ill Patients with Sepsis-Associated Multi-Organ Dysfunction Requiring Extracorporeal Organ Support: A Narrative Review.Microorganisms · 2023Review
- Influence of continuous renal replacement therapy on the plasma concentration of tigecycline in patients with septic shock: A prospective observational study.Frontiers in pharmacology · 2023Article
- UHPLC-MS/MS method for simultaneous quantification of doripenem, meropenem, ciprofloxacin, levofloxacin, pazufloxacin, linezolid, and tedizolid in filtrate during continuous renal replacement therapy.Journal of clinical laboratory analysis · 2023Article
- Comprehensive analysis of cytokine adsorption properties of polymethyl methacrylate (PMMA) membrane material.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2022Article
- Effect of Continuous Renal Replacement Therapy with the oXiris Hemofilter on Critically Ill Patients: A Narrative Review.Journal of clinical medicine · 2022Review
- Cefepime Extraction by Extracorporeal Life Support Circuits.The journal of extra-corporeal technology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to assess the adsorption of selected antibiotics: vancomycin, gentamicin, ciprofloxacine and tigecycline in an experimental continuous veno-venous hemofiltration circuit with the use of both polyethyleneimine-treated polyacrylonitrile (PAN) and the polysulfone (PS) filter membranes. The crystalloid fluid dosed with one of antibiotic was pumped from a reservoir through a hemofiltration circuit (with PAN or PS membrane) and back to reservoir. All ultrafiltrate was also returned to the reservoir. During the procedures samples were collected from the post-hemofilter port at 5, 15, 30, 45, 60, 90, and 120 min. To determine spontaneous degradation of the antimicrobials, an additional bag with each study drug was prepared, which was not attached to the hemofiltration circuit. The samples from these bags were used as controls. In the case of vancomycin, gentamycin and tigecycline there was a statistically significant decrease in the drug concentration in the hemofiltration circuit in comparison to the control for PAN membrane (P < 0.05, P < 0.001, P < 0.001, respectively). In the case of ciprofloxacine adsorption was reversible and the drug concentrations increase to achieve the initial level for both membranes. Our studies indicated that a large portion of the administered dose of antibiotics may be adsorbed on a PAN membrane. In the case of gentamicin and tigecycline this amount is sufficiently big (over 90% of the administered dose) to be of clinical importance. In turn, adsorption on PS membranes is clearly lower (up to 10%) and may be clinically unimportant.
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Registered trials
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