Evidence map›Paper›PMID 31630212›Full record

ArticleInternational journal of colorectal disease2019

Clinicopathological characteristics and frequency of multiple rectal neuroendocrine tumors: a single-center retrospective study.

Yusuke Nishikawa, Akiko Chino, Daisuke Ide, Shoichi Saito, Masahiro Igarashi, Manabu Takamatsu, Junko Fujisaki, Yoshinori Igarashi

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Rectal neuroendocrine tumors: Update.World journal of gastrointestinal oncology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yusuke NishikawaDepartment of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Akiko ChinoDepartment of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan. akiko.chino@jfcr.or.jp.
Daisuke IdeDepartment of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Shoichi SaitoDepartment of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Masahiro IgarashiDepartment of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Manabu TakamatsuDivision of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Junko FujisakiDepartment of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Yoshinori IgarashiDepartments of Gastroenterology, Toho University Oomori hospital, Tokyo, Japan.
Japanese Foundation For Cancer Research · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRectal multiple neuroendocrine tumors (M-NETs) are rare, with only few epidemiologic reports on the topic. Therefore, their clinicopathological features are not completely known, and the appropriate treatment strategy has not been established. PURPOSE: This study aimed to compare the clinicopathological malignant potential (lymphatic or venous invasion-positive and lymph node metastasis rates) of M-NETs with that of solitary NETs (S-NETs).

methodsWe retrospectively investigated 369 patients with NETs of the rectum. Patients who underwent colonoscopy at the Cancer Institute Hospital between January 1979 and 2016 and diagnosed with S-NETs were included, and S-NETs were found in 348 patients. Patients with M-NETs were classified into two groups as follows: patients with < 8 tumors (several (S) group, n = 21) and those with ≥ 8 tumors (numerous (N) group, n = 3).

resultsThe overall frequency of M-NETs was 5.7% and that of the N group was 0.8%. The mean tumor diameter in the N group was 6.0 mm (range, 4-8 mm). The lymphatic invasion rates of the S-NETs, and S and N groups of the M-NETs were 8.9%, 5.6%, and 66.7%, respectively. Moreover, the lymph node metastasis rates were 9.2%, 11.1%, and 33.3, respectively.

conclusionsWhile M-NETs in the S and N groups had different characteristics, they were rarer in the N group. The N group may have higher rates of lymphatic invasion and lymph node metastasis regardless of tumor size.

Indexed as

AdultAgedAged, 80 and overFemaleHumansLymphatic MetastasisMaleMiddle AgedNeuroendocrine TumorsRectal NeoplasmsRetrospective StudiesEpidemiology for neuroendocrine tumorGastrointestinal neuroendocrine tumorLymph node metastasisMultiple rectal neuroendocrine tumorNeuroendocrine tumor

Identifiers

PMID31630212
OpenAlexW2981297514

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.