ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Distal Sensory Peripheral Neuropathy in Human Immunodeficiency Virus Type 1-Positive Individuals Before and After Antiretroviral Therapy Initiation in Diverse Resource-Limited Settings.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Does exercise program of endurance and strength improve health-related quality of life in persons living with HIV-related distal symmetrical polyneuropathy? A randomized controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Trial
- Characteristics, impact and management of chronic pain in black women with HIV.International journal of STD & AIDS · 2026Article
- Genotypic investigation of Mycobacterium leprae in patients with relapsing leprosy in Mato Grosso, Brazil.Medical microbiology and immunology · 2025Article
- Article
- Global Prevalence of Chronic Pain in Women with HIV: A Systematic Review and Meta-analysis.Open forum infectious diseases · 2023Review
- Sleep Disturbances and Chronic Pain in People with HIV: Implications for HIV-Associated Neurocognitive Disorders.Current sleep medicine reports · 2022Article
- People living with HIV and the emerging field of chronic pain-what is known about epidemiology, etiology, and management.Current HIV/AIDS reports · 2021Review
- Neurocognitive Effects of Antiretroviral Initiation Among People Living With HIV in Rural Uganda.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Predictors of worsening neuropathy and neuropathic pain after 12 years in people with HIV.Annals of clinical and translational neurology · 2020Article
- Chronic pain in people with HIV: a common comorbidity and threat to quality of life.Pain management · 2020Article
Corrections and comments
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Authors and funding
21 authors at 15 institutions in 8 countries.
Funding
Abstract
backgroundDistal sensory peripheral neuropathy (DSPN) is a complication of human immunodeficiency virus (HIV). We estimate DSPN prevalence in 7 resource-limited settings (RLSs) for combination antiretroviral therapy (cART)-naive people living with HIV (PLWH) compared with matched participants not living with HIV and in PLWH virally suppressed on 1 of 3 cART regimens.
methodsPLWH with a CD4+ count <300 cells/mm3 underwent standardized neurological examination and functional status assessments before and every 24 weeks after starting cART. Matched individuals not living with HIV underwent the same examinations once.Associations between covariates with DSPN at entry were assessed using the χ2 test, and virally suppressed PLWH were assessed using generalized estimating equations.
resultsBefore initiating cART, 21.3% of PLWH had DSPN compared with 8.5% of people not living with HIV (n = 2400; χ2(df = 1) = 96.5; P < .00001). PLWH with DSPN were more likely to report inability to work [χ2(df = 1) = 10.6; P = .001] and depression [χ2(df = 1) = 8.9; P = .003] than PLWH without DSPN. Overall prevalence of DSPN among those virally suppressed on cART decreased: 20.3%, week 48; 15.3%, week 144; and 10.3%, week 192. Incident DSPN was seen in 127 PLWH. Longitudinally, DSPN was more likely in older individuals (P < .001) and PLWH with less education (P = .03). There was no significant association between cART regimen and DSPN.
conclusionsAlthough the prevalence of DSPN decreased following cART initiation in PLWH, further research could identify strategies to prevent or ameliorate residual DSPN after initiating cART in RLSs.
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