ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
DNA Methylation Age and Physical and Cognitive Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
- Exercise and epigenetic ages in older adults with myeloid malignancies.European journal of medical research · 2023Trial
- Exploring epigenetic aging and cognitive change in middle adulthood.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Biological age-acceleration in relation to muscle mass, strength and function: findings from the Hertfordshire Cohort Study.Aging clinical and experimental research · 2026Article
- Association of biological age acceleration with muscle aging phenotype in young and middle-aged adults: a prospective cohort study.GeroScience · 2026Article
- Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.Biological psychiatry global open science · 2026Review
- Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity.JAMA network open · 2026Article
- Functional, molecular, and digital measurements of biological age.The Journal of clinical investigation · 2026Review
- Epigenetic Age and Resilience in the Framingham Heart Study.Neurology open access · 2026Article
- Tracking DNA methylation-based biological age over 8 years and its association with mortality in community-dwelling older adults.Clinical epigenetics · 2026Article
- A feasibility study exploring precarious employment and stress-related health among women.BMC public health · 2026Article
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- The associations between biological markers of aging and appetite loss across adulthood: retrospective case-control data from the INSPIRE-T study.GeroScience · 2026Article
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- Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration.medRxiv : the preprint server for health sciences · 2026Article
- Does leisure activity matter for epigenetic aging? Analyses of arts engagement and physical activity in the UK Household Longitudinal Study.Innovation in aging · 2026Article
- Article
- Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Epigenetic age acceleration, telomere length, and neurocognitive function in long-term survivors of childhood cancer.Nature communications · 2025Article
- Common DNA sequence variation influences epigenetic aging in African populations.Communications biology · 2025Article
- DNA methylation age deviation and cognitive status among older adults in the US, NHANES 1999-2002.medRxiv : the preprint server for health sciences · 2025Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
backgroundDNA methylation (DNAm) age acceleration (AgeAccel) has been shown to be predictive of all-cause mortality but it is unclear what functional aspect(s) of aging it captures. We examine associations between four measures of AgeAccel in adults aged 45-87 years and physical and cognitive performance and their age-related decline.
methodsAgeAccelHannum, AgeAccelHorvath, AgeAccelPheno, and AgeAccelGrim were calculated in the Medical Research Council National Survey of Health and Development (NSHD), National Child Development Study (NCDS) and TwinsUK. Three measures of physical (grip strength, chair rise speed, and forced expiratory volume in one second [FEV1]) and two measures of cognitive (episodic memory and mental speed) performance were assessed.
resultsAgeAccelPheno and AgeAccelGrim, but not AgeAccelHannum and AgeAccelHorvath were related to performance in random effects meta-analyses (n = 1,388-1,685). For example, a 1-year increase in AgeAccelPheno or AgeAccelGrim was associated with a 0.01 mL (95% confidence interval [CI]: 0.01, 0.02) or 0.03 mL (95% CI: 0.01, 0.05) lower mean FEV1 respectively. In NSHD, AgeAccelPheno and AgeAccelGrim at 53 years were associated with age-related decline in performance between 53 and 69 years as tested by linear mixed models (p < .05). In a subset of NSHD participants (n = 482), there was little evidence that change in any AgeAccel measure was associated with change in performance conditional on baseline performance.
conclusionsWe found little evidence to support associations between the first generation of DNAm-based biomarkers of aging and age-related physical or cognitive performance in midlife to early old age. However, there was evidence that the second generation biomarkers, AgeAccelPheno and AgeAccelGrim, could act as makers of an individual's healthspan as proposed.
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