ArticleNeuroImage. Clinical2019
Every hit matters: White matter diffusivity changes in high school football athletes are correlated with repetitive head acceleration event exposure.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Uncovering the hidden effects of repetitive subconcussive head impact exposure: A mega-analytic approach characterizing seasonal brain microstructural changes in contact and collision sports athletes.Human brain mapping · 2024Pooled it
- Head Impact Research Using Inertial Sensors in Sport: A Systematic Review of Methods, Demographics, and Factors Contributing to Exposure.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Chronic traumatic encephalopathy: A devastating legacy of repetitive concussion.Neurobiology of disease · 2026Review
- Evaluating Transferability of ComBat Harmonization of Diffusion Tensor Magnetic Resonance Imaging Data.Annals of biomedical engineering · 2026Article
- Molecular abnormalities scale across three models of cerebral injury.Frontiers in molecular neuroscience · 2026Article
- Remodeling and Characterization Analysis of Corticospinal Tract in Patients with Intracerebral Hemorrhage in the Basal Ganglia.Translational stroke research · 2025Article
- Clinical utility of diffusion tensor imaging in sport-related concussion: a systematic review.BJR open · 2025Article
- Quantified Head-Ball Impacts in Soccer: A Preliminary, Prospective Study.Neurotrauma reports · 2025Article
- Cognitive implications of white matter microstructural changes in individuals with low heart rate variability: a NODDI study.Frontiers in neurology · 2025Article
- Longitudinal changes in resting state fMRI brain self-similarity of asymptomatic high school American football athletes.Scientific reports · 2024Article
- Design Considerations for the Attenuation of Translational and Rotational Accelerations in American Football Helmets.Journal of biomechanical engineering · 2023Article
- Quantifying the Magnitude and Longevity of the Effect of Repetitive Head Impacts in Adolescent Soccer Players: Deleterious Effect of Long Headers Extend Beyond a Month.Neurotrauma reports · 2023Article
- Longitudinal, prospective study of head impacts in male high school football players.PloS one · 2023Article
- A window into eye movement dysfunction following mTBI: A scoping review of magnetic resonance imaging and eye tracking findings.Brain and behavior · 2022Article
- Cumulative strain-based metrics for predicting subconcussive head impact exposure-related imaging changes in a cohort of American youth football players.Journal of neurosurgery. Pediatrics · 2022Article
- Metabolomic response to collegiate football participation: Pre- and Post-season analysis.Scientific reports · 2022Article
- A preliminary model of football-related neural stress that integrates metabolomics with transcriptomics and virtual reality.iScience · 2022Article
- Eye Movements in Mild Traumatic Brain Injury: Ocular Biomarkers.Journal of eye movement research · 2022Article
- Normalized Brain Tissue-Level Evaluation of Volumetric Changes of Youth Athletes Participating in Collision Sports.Neurotrauma reports · 2022Article
- Regional White Matter Diffusion Changes Associated with the Cumulative Tensile Strain and Strain Rate in Nonconcussed Youth Football Players.Journal of neurotrauma · 2021Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence of short-term alterations in brain physiology associated with repeated exposure to moderate intensity subconcussive head acceleration events (HAEs), prompts the question whether these alterations represent an underlying neural injury. A retrospective analysis combining counts of experienced HAEs and longitudinal diffusion-weighted imaging explored whether greater exposure to incident mechanical forces was associated with traditional diffusion-based measures of neural injury-reduced fractional anisotropy (FA) and increased mean diffusivity (MD). Brains of high school athletes (N = 61) participating in American football exhibited greater spatial extents (or volumes) experiencing substantial changes (increases and decreases) in both FA and MD than brains of peers who do not participate in collision-based sports (N = 15). Further, the spatial extents of the football athlete brain exhibiting traditional diffusion-based markers of neural injury were found to be significantly correlated with the cumulative exposure to HAEs having peak translational acceleration exceeding 20 g. This finding demonstrates that subconcussive HAEs induce low-level neurotrauma, with prolonged exposure producing greater accumulation of neural damage. The duration and extent of recovery associated with periods in which athletes do not experience subconcussive HAEs now represents a priority for future study, such that appropriate participation and training schedules may be developed to minimize the risk of long-term neurological dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.