ArticleDevelopmental cognitive neuroscience2019
Maternal overprotection in childhood is associated with amygdala reactivity and structural connectivity in adulthood.
Article in Developmental cognitive neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Neural Mechanisms of Social Homeostasis: Dynamic Range Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Perceived Maternal Overprotection and Amygdala Functional Connectivity in Children: Implications for Childhood Depressive Symptoms.Depression and anxiety · 2026Article
- The Psychopathological Domains of Attachment Trauma: A Proposal for a Clinical Conceptualization.Clinical neuropsychiatry · 2025Article
- Longitudinal associations between white matter integrity, early life adversities, and treatment response following cognitive-behavioral therapy in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Neurodevelopmental Pathways from Temperamental Fear to Anxiety.Current topics in behavioral neurosciences · 2025Review
- Neighborhood disadvantage and parenting predict longitudinal clustering of uncinate fasciculus microstructural integrity and clinical symptomatology in adolescents.Developmental cognitive neuroscience · 2024Article
- Associations between perceived parenting, brain activity and connectivity, and depression symptoms in Brazilian adolescents.International journal of adolescence and youth · 2024Article
- Normative range parenting and the developing brain: A scoping review and recommendations for future research.The European journal of neuroscience · 2022Article
- Ecological stress, amygdala reactivity, and internalizing symptoms in preadolescence: Is parenting a buffer?Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Caregiving influences on emotional learning and regulation: Applying a sensitive period model.Current opinion in behavioral sciences · 2020Article
- Mental health among Vietnamese urban late adolescents: The association of parenting styles.Health psychology openArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Recently, we reported that variability in early-life caregiving experiences maps onto individual differences in threat-related brain function. Here, we extend this work to provide further evidence that subtle variability in specific features of early caregiving shapes structural and functional connectivity between the amygdala and medial prefrontal cortex (mPFC) in a cohort of 312 young adult volunteers. Multiple regression analyses revealed that participants who reported higher maternal overprotection exhibited increased amygdala reactivity to explicit signals of interpersonal threat but not implicit signals of broad environmental threat. While amygdala functional connectivity with regulatory regions of the mPFC was not significantly associated with maternal overprotection, participants who reported higher maternal overprotection exhibited relatively decreased structural integrity of the uncinate fasciculus (UF), a white matter tract connecting these same brain regions. There were no significant associations between structural or functional brain measures and either maternal or paternal care ratings. These findings suggest that an overprotective maternal parenting style during childhood is associated with later functional and structural alterations of brain regions involved in generating and regulating responses to threat.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.