ArticleOsteoarthritis and cartilage2020
Chondrocalcinosis is associated with increased knee joint degeneration over 4 years: data from the Osteoarthritis Initiative.
Article in Osteoarthritis and cartilage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- The association between articular calcium crystal deposition and knee osteoarthritis, joint pain and inflammation: a cross-sectional study.Skeletal radiology · 2025Trial
- Clinical applications of UTE-T2* in knee MRI.Skeletal radiology · 2026Review
- Imaging and management of calcium pyrophosphate deposition disease.Skeletal radiology · 2025Review
- Chondrocalcinosis and incident knee osteoarthritis: findings from 2 large prospective cohorts with 20 years of follow-up.Annals of the rheumatic diseases · 2025Observational
- Intra-Articular Mineralization on Computerized Tomography of the Knee and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study.Arthritis & rheumatology (Hoboken, N.J.) · 2024Article
- A New Era for Calcium Pyrophosphate Deposition Disease Research: The First-Ever Calcium Pyrophosphate Deposition Disease Classification Criteria and Considerations for Measuring Outcomes in Calcium Pyrophosphate Deposition Disease.Gout, urate, and crystal deposition disease · 2024Article
- Efficacy of a single ultrasound-guided injection of high molecular weight hyaluronic acid combined with collagen tripeptide in patients with knee osteoarthritis and chondrocalcinosis.Frontiers in medicine · 2024Article
- Relation of Intra-Articular Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the MOST Study.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Clinical application of ultrashort echo time (UTE) and zero echo time (ZTE) magnetic resonance (MR) imaging in the evaluation of osteoarthritis.Skeletal radiology · 2023Review
- Prevalence of intra-articular mineralization on knee computed tomography: the multicenter osteoarthritis study.Osteoarthritis and cartilage · 2023Article
- Radiographically detectable intra-articular mineralization: Predictor of knee osteoarthritis outcomes or only an indicator of aging? A brief report from the osteoarthritis initiative.Osteoarthritis and cartilage open · 2023Article
- Chondrocalcinosis and Osteoarthritis: A Literature Review.European journal of rheumatology · 2023Article
- Linking physical activity with clinical, functional, and structural outcomes: an evidence map using the Osteoarthritis Initiative.Clinical rheumatology · 2022Review
- The Gasotransmitter Hydrogen Sulfide (HAntioxidants (Basel, Switzerland) · 2021Article
- A critical review of the available evidence on the diagnosis and clinical features of CPPD: do we really need imaging?Clinical rheumatology · 2021Review
- Association of anti-thyroid antibodies with radiographic knee osteoarthritis and chondrocalcinosis: a NHANES III study.Therapeutic advances in musculoskeletal disease · 2021Article
- The effect of vitamin K insufficiency on histological and structural properties of knee joints in aging mice.Osteoarthritis and cartilage open · 2020Article
- Interpretation of Cartilage Damage at Routine Clinical MRI: How to Match Arthroscopic Findings.Radiographics : a review publication of the Radiological Society of North America, IncReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo determine if presence of calcium-containing crystals (CaC) is associated with increased knee joint degeneration over 4 years and assess if total number of CaCs deposited is a useful measure of disease burden.
designSeventy subjects with CaCs in right knees at baseline were selected from the Osteoarthritis Initiative and matched to 70 subjects without evidence of CaCs. T1-weighted gradient-echo sequences were used to confirm presence of CaCs and count the numbers of distinct circumscribed CaCs. Morphological abnormalities were assessed at baseline and 4-year follow-up using the modified semi-quantitative Whole-Organ Magnetic Resonance Imaging Score (WORMS). Linear regression models were used to analyze the associations between presence of CaCs at baseline and changes in WORMS and to analyze the associations between numbers of circumscribed CaCs at baseline and changes in WORMS.
resultsPresence of CaCs was associated with increased cartilage degeneration in the patella (coefficient: 0.33; 95% confidence interval (CI): 0.04-0.63), the medial femur (coefficient: 0.51; 95% CI: 0.18-0.83), the lateral tibia (coefficient: 0.36; 95% CI: 0.01-0.71) as well as the medial and lateral meniscus (coefficient: 0.38; 95% CI: 0.00-0.75 and coefficient: 0.72; 95% CI: 0.12-1.32). Knees with higher numbers of CaCs had increased cartilage degeneration in the patella and medial femur (coefficient: 0.09; 95% CI: 0.05-0.14; P < 0.001 and coefficient: 0.08; 95% CI: 0.02-0.14; P = 0.005).
conclusionsCaCs were associated with increased cartilage and meniscus degeneration over a period of 4 years. Assessing the number of CaC depositions may be useful to evaluate risk of onset and worsening of degenerative disease.
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