ArticleMedical hypotheses2020
A hypothetical proposal for association between migraine and Meniere's disease.
Article in Medical hypotheses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- [Efficacy analysis of anti-migraine therapy for acute low-frequency hearing loss and investigation of its mechanisms].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Trial
- Meniere's Disease and Migraine: Effect of Migraine Medications on Symptoms of Meniere's Disease.The Laryngoscope · 2026Article
- Modern Perspectives on the Mechanisms and Non-Genetic Factors in Ménière's Disease-A Narrative Review.Biomedicines · 2026Review
- Article
- Expanding the Spectrum of Central Sensitivity Syndrome: Integrating Otologic Migraine as Otologic Central Sensitivity Syndrome.Brain sciences · 2026Review
- Prevalence and Clinical Significance of Aural Symptoms in Vestibular Migraine with and Without Ménière's Disease.Journal of clinical medicine · 2026Article
- Immunological mechanisms in Meniere's disease.Frontiers in immunology · 2025Review
- Vestibular migraine: course of symptoms during a four-year follow-up.Frontiers in neurology · 2025Article
- Neurological and Systemic Pitfalls in the Diagnosis of Cluster Headaches: A Case-Based Review.Current neurology and neuroscience reports · 2024Review
- Did Martin Luther suffer from vestibular migraine?European journal of neurology · 2024Article
- Sensational site: the sodium pump ouabain-binding site and its ligands.American journal of physiology. Cell physiology · 2024Review
- Migraine management for the otolaryngologist.Laryngoscope investigative otolaryngology · 2023Review
- Management of Migraine-Associated Vestibulocochlear Disorders.Audiology research · 2023Review
- Cerebral Small Vessel Disease in Elderly Patients With Menière's Disease.Otology & neurotology open · 2023Article
- A proposed association between subjective nonpulsatile tinnitus and migraine.World journal of otorhinolaryngology - head and neck surgery · 2023Review
- Functional and Molecular Markers for Hearing Loss and Vertigo Attacks in Meniere's Disease.International journal of molecular sciences · 2023Review
- Recent advances in understanding molecular bases of Ménière's disease.Faculty reviews · 2023Review
- Migrainous Vertigo, Tinnitus, and Ear Symptoms and Alternatives.Otolaryngologic clinics of North America · 2022Review
- Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study.Journal of clinical medicine · 2021Article
- Endolymphatic Hydrops in Patients With Vestibular Migraine and Concurrent Meniere's Disease.Frontiers in neurology · 2021Article
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4 authors at 2 institutions in 1 country.
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Abstract
Meniere's disease (MD) is a chronic condition affecting the inner ear whose precise etiology is currently unknown. We propose the hypothesis that MD is a migraine-related phenomenon which may have implications for future treatment options for both diseases. The association between MD and migraine is both an epidemiological and a mechanistic one, with up to 51% of individuals with MD experiencing migraine compared to 12% in the general population. The presence of endolymphatic hydrops in those with MD may be the factor that unites the two conditions, as hydropic inner ears have an impaired ability to maintain homeostasis. Migraine headaches are theorized to cause aura and symptoms via spreading cortical depression that ultimately results in substance P release, alterations in blood flow, and neurogenic inflammation. Chronically hydropic inner ears are less able to auto-regulate against the changes induced by active migraine attacks and may ultimately manifest as MD. This same vulnerability to derangements in homeostasis may also explain the common triggering factors of both MD attacks and migraine headaches, including stress, weather, and diet. Similarly, it may explain the efficacy of common treatments for both diseases: current migraine treatments such as anti-hypertensives and anti-convulsants have shown promise in managing MD. Though the etiology of both MD and migraine is likely multifactorial, further exploration of the association between the two conditions may illuminate how to best manage them in the future. MD is likely a manifestation of cochleovestibular migraine, which occurs as a result of migraine related changes in both the cochlea and vestibule.
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