Evidence map›Paper›PMID 31629064›Full record

ReviewThe Journal of steroid biochemistry and molecular biology2020

Mechanistic homeostasis of vitamin D metabolism in the kidney through reciprocal modulation of Cyp27b1 and Cyp24a1 expression.

Mark B Meyer, J Wesley Pike

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of steroid biochemistry and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. 24R,25(OH)International journal of cancer · 2026
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Kidney deletions of Cyp27b1 fail to reduce serum 1,25(OH)The Journal of steroid biochemistry and molecular biology · 2025
    Article
  18. Article
  19. Article
  20. Critical Role for 24-Hydroxylation in Homeostatic Regulation of Vitamin D Metabolism.The Journal of clinical endocrinology and metabolism · 2025 · on this map
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mark B MeyerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA. Electronic address: markmeyer@wisc.edu.
J Wesley PikeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, 53706, USA.
University of Wisconsin–Madison · US

Funding

Regulatory Mechanisms of Renal Vitamin D Activation and DegradationR01DK117475 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2018 to 2022
$2.0M
NIDDK NIH HHS R01 DK117475
6 · The paper itself

Abstract

Cyp27b1 and Cyp24a1 are reciprocally regulated in the kidney by the key hormones PTH, FGF23, and 1,25(OH)

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseAnimalsCalcitriolCalciumFibroblast Growth Factor-23Fibroblast Growth FactorsGene Expression Regulation, EnzymologicHomeostasisHumansKidneyParathyroid HormoneSignal TransductionVitamin DVitamin D3 24-Hydroxylase25-Hydroxyvitamin D3 1-alpha-HydroxylaseCalcitriolCalciumFGF23 protein, humanFgf23 protein, mouseFibroblast Growth Factor-23Fibroblast Growth FactorsParathyroid HormoneVitamin DVitamin D3 24-Hydroxylase1,25(OH)(2)D(3)ChIP-seqCRISPR/Cas9Cyp24a1Cyp27b1-KOCytochrome P450Fibroblast growth factor 23 (FGF23)Gene regulationParathyroid hormone (PTH)Vitamin D

Identifiers

PMID31629064
PMCPMC6954286
OpenAlexW2980919728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.