ReviewJMIR mental health2019
Conversational Agents in the Treatment of Mental Health Problems: Mixed-Method Systematic Review.
Review in JMIR mental health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04859647 (Client-led Online Therapy for People Diagnosed With Bipolar Disorder), which is not on this map. Cited by 116 papers, 21 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Client-led Online Therapy for People Diagnosed With Bipolar Disorder
Who cites it
116 citing papers in PubMed, 21 syntheses or guidelines pooled it.
- Effectiveness of Chatbots in Mental Health Screening and Assessment: Systematic Review.JMIR mental health · 2026Pooled it
- Usability and User Experience Assessment of Health Care Conversational Agents Using Validated Subjective Instruments: Systematic Review and Comparative Analysis.JMIR human factors · 2026Pooled it
- The Emerging Roles of AI in Self-Directed Stress Management: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Efficacy, User Engagement, and Acceptability of Cognitive Behavioral Therapy-Oriented Psychological Chatbots for Adults With Depressive and/or Anxiety Symptoms: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Chatbot interventions for improving mental health among people in Asia: a systematic review and meta-analysis of randomised controlled trials.BMJ health & care informatics · 2026Pooled it
- The use of chatbots as interventions for mental health conditions: scoping review of systematic reviews and meta-analyses.Frontiers in digital health · 2026Pooled it
- Generative AI Mental Health Chatbots as Therapeutic Tools: Systematic Review and Meta-Analysis of Their Role in Reducing Mental Health Issues.Journal of medical Internet research · 2025Pooled it
- Conversational agent-based interventions for lifestyle behavior modification in older adults: a systematic review.Systematic reviews · 2025Pooled it
- The Effectiveness of AI Chatbots in Alleviating Mental Distress and Promoting Health Behaviors Among Adolescents and Young Adults: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- The application of artificial intelligence in the field of mental health: a systematic review.BMC psychiatry · 2025Pooled it
- Unleashing the potential of chatbots in mental health: bibliometric analysis.Frontiers in psychiatry · 2025Pooled it
- Empathic Conversational Agent Platform Designs and Their Evaluation in the Context of Mental Health: Systematic Review.JMIR mental health · 2024Pooled it
- Effectiveness and Acceptability of Conversational Agents for Smoking Cessation: A Systematic Review and Meta-analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Pooled it
- Conversational Agents for Body Weight Management: Systematic Review.Journal of medical Internet research · 2023Pooled it
- Conversational Agent Interventions for Mental Health Problems: Systematic Review and Meta-analysis of Randomized Controlled Trials.Journal of medical Internet research · 2023Pooled it
- Artificial Intelligence-Based Chatbots for Promoting Health Behavioral Changes: Systematic Review.Journal of medical Internet research · 2023Pooled it
- Barriers to and Facilitators of Using eHealth to Support Gestational Diabetes Mellitus Self-management: Systematic Literature Review of Perceptions of Health Care Professionals and Women With Gestational Diabetes Mellitus.Journal of medical Internet research · 2022Pooled it
- Effectiveness and acceptability of conversational agents for sexual health promotion: a systematic review and meta-analysis.Sexual health · 2022Pooled it
- Changes to the Psychiatric Chatbot Landscape: A Systematic Review of Conversational Agents in Serious Mental Illness: Changements du paysage psychiatrique des chatbots: une revue systématique des agents conversationnels dans la maladie mentale sérieuse.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2021Pooled it
- Computer-Controlled Virtual Humans in Patient-Facing Systems: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2020Pooled it
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of conversational agent interventions (including chatbots and robots) in mental health is growing at a fast pace. Recent existing reviews have focused exclusively on a subset of embodied conversational agent interventions despite other modalities aiming to achieve the common goal of improved mental health.
objectiveThis study aimed to review the use of conversational agent interventions in the treatment of mental health problems.
methodsWe performed a systematic search using relevant databases (MEDLINE, EMBASE, PsycINFO, Web of Science, and Cochrane library). Studies that reported on an autonomous conversational agent that simulated conversation and reported on a mental health outcome were included.
resultsA total of 13 studies were included in the review. Among them, 4 full-scale randomized controlled trials (RCTs) were included. The rest were feasibility, pilot RCTs and quasi-experimental studies. Interventions were diverse in design and targeted a range of mental health problems using a wide variety of therapeutic orientations. All included studies reported reductions in psychological distress postintervention. Furthermore, 5 controlled studies demonstrated significant reductions in psychological distress compared with inactive control groups. In addition, 3 controlled studies comparing interventions with active control groups failed to demonstrate superior effects. Broader utility in promoting well-being in nonclinical populations was unclear.
conclusionsThe efficacy and acceptability of conversational agent interventions for mental health problems are promising. However, a more robust experimental design is required to demonstrate efficacy and efficiency. A focus on streamlining interventions, demonstrating equivalence to other treatment modalities, and elucidating mechanisms of action has the potential to increase acceptance by users and clinicians and maximize reach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.