Evidence map›Paper›PMID 31628732›Full record

ArticleJournal of cellular and molecular medicine2019

A novel single-chain enzyme complex with chain reaction properties rapidly producing thromboxane A

Yan Li, Qun-Ying Li, Qing-Lan Ling, Shui-Ping So, Ke-He Ruan

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Yan LiDepartment of Pharmacological and Pharmaceutical Sciences, Center for Experimental Therapeutics and Pharmacoinformatics, College of Pharmacy, University of Houston, Houston, TX, USA.ORCID 0000-0002-9741-1185
Qun-Ying LiDepartment of Pharmacological and Pharmaceutical Sciences, Center for Experimental Therapeutics and Pharmacoinformatics, College of Pharmacy, University of Houston, Houston, TX, USA.
Qing-Lan LingDepartment of Pharmacological and Pharmaceutical Sciences, Center for Experimental Therapeutics and Pharmacoinformatics, College of Pharmacy, University of Houston, Houston, TX, USA.
Shui-Ping SoDepartment of Pharmacological and Pharmaceutical Sciences, Center for Experimental Therapeutics and Pharmacoinformatics, College of Pharmacy, University of Houston, Houston, TX, USA.
Ke-He RuanDepartment of Pharmacological and Pharmaceutical Sciences, Center for Experimental Therapeutics and Pharmacoinformatics, College of Pharmacy, University of Houston, Houston, TX, USA.
University of Houston · USSecond Affiliated Hospital of Zhejiang University · CN

Funding

Prostaglandin I synthase, Thromboxane A synthase & Prostaglandin E synthaseR01HL056712 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RUAN, KE-HE · 2000 to 2009
$2.3M
STRUCTURE &FUNCTION RELATIONSHIP: PROSTANOID RECEPTORSR01HL079389 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RUAN, KE-HE · 2005 to 2008
$1.4M
NHLBI NIH HHS R01 HL056712NHLBI NIH HHS R01 HL079389NIH HHS RO1 HL56712NIH HHS RO1 HL79389
6 · The paper itself

Abstract

Uncontrollable bleeding is still a worldwide killer. In this study, we aimed to investigate a novel approach to exhibit effective haemostatic properties, which could possibly save lives in various bleeding emergencies. According to the structure-based enzymatic design, we have engineered a novel single-chain hybrid enzyme complex (SCHEC), COX-1-10aa-TXAS. We linked the C-terminus of cyclooxygenase-1 (COX-1) to the N-terminus of the thromboxane A

Indexed as

Amino AcidsAnimalsAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 1DinoprostoneEpoprostenolHEK293 CellsHemorrhageHemostaticsHumansMice, TransgenicPlatelet AggregationProstaglandin H2Recombinant Fusion ProteinsThromboxane A2Thromboxane-A SynthaseAmino AcidsAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 1DinoprostoneEpoprostenolHemostaticsProstaglandin H2Recombinant Fusion ProteinsThromboxane A2Thromboxane-A Synthaseenzyme engineeringhaemostasisprostanoidsthromboxane A2

Identifiers

PMID31628732
PMCPMC6850917
OpenAlexW2981035168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.