ArticleBrain imaging and behavior2020
Altered functional connectivity of the amygdala in Crohn's disease.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Mapping the neuroimaging landscape of inflammatory bowel disease: a bibliometric analysis and systematic scoping review.Frontiers in neuroscience · 2026Pooled it
- Resting-state functional MRI activity and connectivity in inflammatory bowel disease: a systematic review.Neuroradiology · 2025Pooled it
- Altered resting-state brain functional activities and networks in Crohn's disease: a systematic review.Frontiers in neuroscience · 2024Pooled it
- Neural correlates of co-occurring pain and depression: an activation-likelihood estimation (ALE) meta-analysis and systematic review.Translational psychiatry · 2022Pooled it
- Current approaches to studying human resting-state function in inflammatory bowel disease.Journal of the Canadian Association of Gastroenterology · 2025Article
- Altered Function and Structure of the Cerebellum Associated with Gut-Brain Regulation in Crohn's Disease: a Structural and Functional MRI Study.Cerebellum (London, England) · 2024Article
- Identification of neural alterations in patients with Crohn's disease with a novel multiparametric brain MRI-based radiomics model.Insights into imaging · 2024Article
- The different impacts of pain-related negative emotion and trait negative emotion on brain function in patients with inflammatory bowel disease.Scientific reports · 2024Article
- Evidence linking gut-brain axis and Crohn's disease, focusing on neurotrophic dysfunctions and radiological imaging analysis - a systematic review.American journal of translational research · 2024Article
- Abnormal Amygdala Subregion Functional Connectivity in Patients with Crohn's Disease with or without Anxiety and Depression.Behavioural neurology · 2024Article
- Functional magnetic resonance imaging providing the brain effect mechanism of acupuncture and moxibustion treatment for depression.Frontiers in neurology · 2023Review
- Brain signatures of chronic gut inflammation.Frontiers in psychiatry · 2023Article
- Modulation of visceral pain by brain nuclei and brain circuits and the role of acupuncture: a narrative review.Frontiers in neuroscience · 2023Review
- Inflammatory bowel disease cross-sectional imaging: What's new?United European gastroenterology journal · 2022Review
- Evaluation of Subcortical Structure Volumes in Patients with Non-Specific Digestive Diseases.Diagnostics (Basel, Switzerland) · 2022Article
- Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut-brain communications.Frontiers in immunology · 2022Review
- Altered Intra- and Inter-Network Functional Connectivity in Patients With Crohn's Disease: An Independent Component Analysis-Based Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2022Article
- Is It a Gut Feeling? Bodily Sensations Associated With the Experience of Valence and Arousal in Patients With Inflammatory Bowel Disease.Frontiers in psychiatry · 2022Article
- Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn's disease.Frontiers in neuroscience · 2022Article
- Acupuncture decreases amygdala functional connectivity in subjective tinnitus.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Crohn's disease (CD), a chronic inflammatory bowel disease, involved in brain structural and functional changes, including the amygdala. Amygdala is a key structure in the limbic system and its related circuits are implicated in processing of emotion, pain and sensory. However, limited study of the amygdala is elucidated in CD. This study mainly investigated altered functional connectivity (FC) of the amygdala in CD patients during resting-state. Magnetic resonance imaging scans were acquired from 42 CD patients and 35 healthy controls (HCs). Whole amygdala bilaterally were selected as regions of interest (ROIs). Voxel-based morphometry and FC methods were applied to investigate the differences of structure or intrinsic connectivity of the amygdala between the two groups, separately. Pearson correlations were performed to explore relationships between the clinical characteristics and neuroimaging findings in CD patients. Based on the whole amygdala bilaterally as ROIs, compared with HCs, CD patients showed no statistical differences of grey matter destiny but exhibited decreased FC between the amygdala and insula, parahippocampus, as well as anterior middle cingulate cortex/dorsal anterior cingulate cortex. CD patients had negative correlation between the disease duration and amygdala-insula connectivity. In the patient group, patients with higher anxiety or depression scores revealed increased FC of the amygdala with thalamus and orbitofrontal cortex. Our results reveal that aberrant FC of the amygdala may be involved in processing of visceral pain and sensation, and emotion in CD. These findings may further enhance the understanding of neural mechanisms of CD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.