Evidence map›Paper›PMID 31628514›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Dynamic patterns of [

Ian Alberts, Christos Sachpekidis, Eleni Gourni, Silvan Boxler, Tobias Gross, George Thalmann, Kambiz Rahbar, Axel Rominger, Ali Afshar-Oromieh

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Biphasic contrast-enhanced [EJNMMI research · 2025
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  4. Comparison of clinical performance between late and standard total-body [European journal of nuclear medicine and molecular imaging · 2025
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  5. The superior detection rate of total-body [European journal of nuclear medicine and molecular imaging · 2024
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  6. Combined whole-body dynamic and static PET/CT with low-dose [European journal of nuclear medicine and molecular imaging · 2024
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  7. Total-body [European journal of nuclear medicine and molecular imaging · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Evaluation of [EJNMMI research · 2022
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  14. Comparing the clinical performance and cost efficacy of [European journal of nuclear medicine and molecular imaging · 2022
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  15. Diagnostic accuracy of [European journal of nuclear medicine and molecular imaging · 2022
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  16. Article
  17. Article
  18. Differences in Distribution and Detection Rate of the [Pharmaceuticals (Basel, Switzerland) · 2021
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  19. Article
  20. Pharmacokinetic studies of [European journal of nuclear medicine and molecular imaging · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ian AlbertsDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstr. 18, 3010, Bern, Switzerland. ian.alberts@insel.ch.ORCID 0000-0003-2095-2263
Christos SachpekidisDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstr. 18, 3010, Bern, Switzerland.
Eleni GourniDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstr. 18, 3010, Bern, Switzerland.
Silvan BoxlerDepartment of Urology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Tobias GrossDepartment of Urology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
George ThalmannDepartment of Urology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Kambiz RahbarDepartment of Nuclear Medicine, University Hospital Münster, Münster, Germany.
Axel RomingerDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstr. 18, 3010, Bern, Switzerland.
Ali Afshar-OromiehDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstr. 18, 3010, Bern, Switzerland.
University of Bern · CHUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDual-time point PET/CT scanning with [

methodsOne hundred consecutive patients with biochemically recurrent PC who received standard and late [

resultsSeventy-nine of 100 patients had PSMA-positive scans, in whom a total of 185 individual PSMA-positive lesions were identified. These were morphologically characterised as bone lesions (n = 48), solid organ lesions (n = 3), lymph node (LN) lesions (n = 78) and locally recurrent lesions in the prostatic fossa or seminal vesicles (n = 56). The relative uptake between standard and late imaging was considered; all lesions classified as local recurrence presented with increasing (86%) or stable patterns of tracer uptake (14%). In contrast, only 58% of bone lesions exhibited increasing tracer uptake, with 21% exhibiting a stable pattern and 21% exhibiting a decreasing tracer uptake at late imaging.

conclusionA heterogeneous pattern of dynamic tracer uptake was observed, with a largely increasing pattern observed for locally recurrent lesions and lymph nodes and a significant proportion of bone lesions exhibiting decreasing tracer uptake. The results are of significance not only in the imaging and identification of PC lesions, but they also have implications for PSMA-directed ligand therapy.

Indexed as

Positron Emission Tomography Computed TomographyProstatic NeoplasmsEdetic AcidGallium RadioisotopesHumansMaleNeoplasm Recurrence, LocalOligopeptidesRetrospective StudiesEdetic AcidGallium RadioisotopesOligopeptidesGanglionPET/CTPositron emission tomographyProstate cancerProstate-specific membrane antigenPSMA

Identifiers

PMID31628514
OpenAlexW2980656148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.