Evidence map›Paper›PMID 31628379›Full record

ArticleScientific reports2019

Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates.

Olof Eriksson, Irina Velikyan, Torsten Haack, Martin Bossart, Andreas Evers, Iina Laitinen, Philip J Larsen, Oliver Plettenburg, Akihiro Takano, Christer Halldin and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. New Long-Acting [Journal of medicinal chemistry · 2023
    Article
  2. Review
  3. Automated GMP-Compliant Production of [Pharmaceuticals (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Olof ErikssonAntaros Medical AB, Mölndal, Sweden. olof.eriksson@antarosmedical.com.ORCID http://orcid.org/0000-0002-2515-8790
Irina VelikyanPET Centre, Centre for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden.
Torsten HaackSanofi-Aventis, Frankfurt, Germany.
Martin BossartSanofi-Aventis, Frankfurt, Germany.
Andreas EversSanofi-Aventis, Frankfurt, Germany.
Iina LaitinenSanofi-Aventis, Frankfurt, Germany.
Philip J LarsenSanofi-Aventis, Frankfurt, Germany.
Oliver PlettenburgSanofi-Aventis, Frankfurt, Germany.
Akihiro TakanoDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.
Christer HalldinDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.
Gunnar AntoniPET Centre, Centre for Medical Imaging, Uppsala University Hospital, Uppsala, Sweden.
Lars JohanssonAntaros Medical AB, Mölndal, Sweden.
Stefan PierrouAntaros Medical AB, Mölndal, Sweden.
Michael WagnerSanofi-Aventis, Frankfurt, Germany. michael.wagner@sanofi.com.
Sanofi (Germany) · DEAntaros Medical (Sweden) · SEUppsala University · SELeibniz University Hannover · DENanyang Technological University · SGSanofi (France) · FRScience for Life Laboratory · SEStockholm County Council · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The glucagon receptor (GCGR) is an emerging target in anti-diabetic therapy. Reliable biomarkers for in vivo activity on the GCGR, in the setting of dual glucagon-like peptide 1/glucagon (GLP-1/GCG) receptor agonism, are currently unavailable. Here, we investigated [

Indexed as

AnimalsBiomarkersFemaleGlucagon-Like Peptide-1 ReceptorHumansLigandsLiverMacaca fascicularisMalePeptidesPositron Emission Tomography Computed TomographyProtein BindingRadiometryRatsRats, Sprague-DawleyReceptors, GlucagonBiomarkersGlucagon-Like Peptide-1 ReceptorLigandsPeptidesReceptors, Glucagon

Identifiers

PMID31628379
PMCPMC6800434
OpenAlexW2980328705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.