ArticleNature communications2019
Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 86 citations in OpenAlex.
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- Brain-gonad axes harmonize male mating drive and reproductive strategy via steroid hormones.Nature communications · 2026Article
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- High-resolution single-cell analyses reveal evolutionary constraints and evolvability of sexual circuits inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts.Cell reports · 2025Article
- Identification and Expression Analysis of G-Protein-Coupled Receptors Provide Insights into Functional and Mechanistic Responses to Herbivore-Induced Plant Volatiles ofInternational journal of molecular sciences · 2025Article
- Movement and Dispersion Parameters Characterizing the Group Behavior ofAnimals : an open access journal from MDPI · 2025Article
- Comparative Perspectives on Neuropeptide Function and Social Isolation.Biological psychiatry · 2025Review
- High-resolution comparative single-cell transcriptomics ofbioRxiv : the preprint server for biology · 2025Article
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- A brief history of insect neuropeptide and peptide hormone research.Cell and tissue research · 2025Review
- Localization of Cholecystokinin/Sulfakinin Neuropeptides in Biomphalaria glabrata, an Intermediate Host for Schistosomiasis.The Journal of comparative neurology · 2025Article
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- Activation of the G protein-coupled sulfakinin receptor inhibits blood meal intake in the mosquito Aedes aegypti.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Comparison of Brain Gene Expression Profiles Associated with Auto-Grooming Behavior betweenGenes · 2024Article
- Changes in the cellular makeup of motor patterning circuits drive courtship song evolution in Drosophila.Current biology : CB · 2024Article
- Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion.Nature communications · 2024Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals perform or terminate particular behaviors by integrating external cues and internal states through neural circuits. Identifying neural substrates and their molecular modulators promoting or inhibiting animal behaviors are key steps to understand how neural circuits control behaviors. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) that functions at single-neuron resolution to suppress male sexual behavior in Drosophila. We found that Dsk neurons physiologically interact with male-specific P1 neurons, part of a command center for male sexual behaviors, and function oppositely to regulate multiple arousal-related behaviors including sex, sleep and spontaneous walking. We further found that the DSK-2 peptide functions through its receptor CCKLR-17D3 to suppress sexual behaviors in flies. Such a neuropeptide circuit largely overlaps with the fruitless-expressing neural circuit that governs most aspects of male sexual behaviors. Thus DSK/CCKLR signaling in the sex circuitry functions antagonistically with P1 neurons to balance arousal levels and modulate sexual behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.