ArticleProceedings of the National Academy of Sciences of the United States of America2019
Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Application of in vitro to in vivo extrapolation (IVIVE) to inform chemical health guidance value derivation-sample case studies comparing neuro-, hepato-, and developmental toxicities.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- T3 enhances neuronal activity in an induced pluripotent stem cell derived model of early human brain development.European thyroid journal · 2026Article
- Dissection of Microglial Heterogeneity and Identification of Pain-Related Subpopulations After Traumatic Brain Injury.Pain research & management · 2026Article
- Integrated Single-cell Analysis Uncovers Regulatory Logic of Cranial Ectoderm Development.bioRxiv : the preprint server for biology · 2025Article
- Thyroid hormone promotes fetal neurogenesis.JCI insight · 2025Article
- Trisomy 21 Disrupts Thyroid Hormones Signaling During Human iPSC-Derived Neural Differentiation In Vitro.Cells · 2025Article
- Mapping Thyroid Hormone Action in the Human Brain.Thyroid : official journal of the American Thyroid Association · 2024Review
- The Potential Role of Thyroid Hormone Therapy in Neural Progenitor Cell Differentiation and Its Impact on Neurodevelopmental Disorders.Molecular neurobiology · 2024Article
- Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development.Scientific reports · 2024Article
- Bypassing the brain barriers: upregulation of serum miR-495 and miR-543-3p reflects thyroid-mediated developmental neurotoxicity in the rat.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Optimized Mass Spectrometry Detection of Thyroid Hormones and Polar Metabolites in Rodent Cerebrospinal Fluid.Metabolites · 2024Article
- Integrative proteome and metabolome analyses reveal molecular basis of the tail resorption during the metamorphic climax ofFrontiers in cell and developmental biology · 2024Article
- Changes in brain structure in subjects with resistance to thyroid hormone due to THRB mutations.Thyroid research · 2023Article
- Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development.Nature methods · 2023Article
- Comparative Analysis of Transcriptome Profiles Reveals Distinct and Organ-Dependent Genomic and Nongenomic Actions of Thyroid Hormone inThyroid : official journal of the American Thyroid Association · 2023Article
- Genetic disorders of thyroid development, hormone biosynthesis and signalling.Clinical endocrinology · 2022Review
- Deficiency of thyroid hormone receptor protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration.Cell death & disease · 2022Article
- Quantitative developmental biology in vitro using micropatterning.Development (Cambridge, England) · 2021Review
- Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi.Thyroid : official journal of the American Thyroid Association · 2021Article
- Best Achievements in Translational and Basic Thyroidology in 2020.Endocrinology and metabolism (Seoul, Korea) · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 8 institutions in 2 countries.
Teresa G KriegerGurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom.
Carla M MoranWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Alberto FranginiGurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom.
W Edward VisserWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Erik SchoenmakersWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Francesco MuntoniDubowitz Neuromuscular Centre and National Institute for Health Research (NIHR) Great Ormond Street (GOS) Hospital Biomedical Research Centre, London WC1N 1EH, United Kingdom.
Chris A ClarkDevelopmental Imaging and Biophysics Section, University College London (UCL) GOS Institute of Child Health, London WC1N 1EH, United Kingdom.
David GadianDevelopmental Imaging and Biophysics Section, University College London (UCL) GOS Institute of Child Health, London WC1N 1EH, United Kingdom.
Wui K ChongDepartment of Radiology, Great Ormond Street Children's Hospital, London WC1N 3JH, United Kingdom.
Adam KuczynskiDepartment of Neuropsychology, Great Ormond Street Children's Hospital, London WC1N 1EH, United Kingdom.
Mehul DattaniDepartment of Endocrinology, Great Ormond Street Children's Hospital and Genetics and Genomic Medicine Programme, UCL GOS Institute of Child Health, London WC1N 1EH, United Kingdom.
Greta LyonsWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Alexandra EfthymiadouDepartment of Endocrinology, University of Ioannina, 45110 Ioannina, Greece.
Faraneh Varga-KhademDepartment of Neuropsychology, Great Ormond Street Children's Hospital, London WC1N 1EH, United Kingdom.
Benjamin D SimonsGurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom.
Krishna ChatterjeeWellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Frederick J LiveseyGurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom; r.livesey@ucl.ac.uk.
Great Ormond Street Hospital · GBUniversity College London · GBUniversity of Cambridge · GBWellcome/Cancer Research UK Gurdon Institute · GBNational Institute for Health Research · GBUniversity of Ioannina · GRWellcome/MRC Institute of Metabolic Science · GBWellcome Trust · GB
Funding
Cancer Research UKDepartment of HealthMedical Research Council G0300117Medical Research Council G0600717Medical Research Council G1002276Medical Research Council MC_PC_12009Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/5Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Wellcome Trust 210755/Z/18/Z
Abstract
Mutations in the thyroid hormone receptor α 1 gene (
Indexed as
MutationAdolescentCell AdhesionCell DifferentiationCell ProliferationChildFemaleHumansInduced Pluripotent Stem CellsMiddle AgedNeural Stem CellsNeurogenesisThyroid Hormone Receptors alphaThyroid Hormone Receptors alphabrain developmentiPSCsthyroid hormone
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.