Evidence map›Paper›PMID 31628184›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Estradiol Enhances the Depolarizing Response to GABA and AMPA Synaptic Conductances in Arcuate Kisspeptin Neurons by Diminishing Voltage-Gated Potassium Currents.

R Anthony DeFazio, Marco A Navarro, Caroline E Adams, Lorin S Milescu, Suzanne M Moenter

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Neuronal plasticity at puberty in mouse hypothalamicProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. New methods to investigate the GnRH pulse generator.Journal of molecular endocrinology · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

R Anthony DeFazioDepartments of Molecular and Integrative Physiology.ORCID 0000-0001-7302-7528
Marco A NavarroDepartment of Biological Sciences, University of Missouri, Columbia, Missouri 65211.
Caroline E AdamsDepartments of Molecular and Integrative Physiology.ORCID 0000-0001-6028-0196
Lorin S MilescuDepartment of Biological Sciences, University of Missouri, Columbia, Missouri 65211.
Suzanne M MoenterDepartments of Molecular and Integrative Physiology, smoenter@umich.edu.ORCID 0000-0001-9812-0497
Laboratoire d’immunologie intégrative du cancer · FRUniversity of Missouri · USUniversity of Michigan · US

Funding

Central Actions of Estrogens: Effects on GnRH NeuronsR01HD041469 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Suzanne M MOENTER · 2002 to 2026
$8.8M
Career Training in Reproductive BiologyT32HD079342 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Suzanne M MOENTER · 2014 to 2026
$2.3M
NICHD NIH HHS R01 HD041469NICHD NIH HHS T32 HD079342
6 · The paper itself

Abstract

Synaptic and intrinsic properties interact to sculpt neuronal output. Kisspeptin neurons in the hypothalamic arcuate nucleus help convey homeostatic estradiol feedback to central systems controlling fertility. Estradiol increases membrane depolarization induced by GABA

Indexed as

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsArcuate Nucleus of HypothalamusEstradiolFemalegamma-Aminobutyric AcidKisspeptinsMiceMice, TransgenicNeuronsPotassium Channels, Voltage-GatedSynapsesSynaptic Transmissionalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidEstradiolgamma-Aminobutyric AcidKisspeptinsPotassium Channels, Voltage-GatedAMPAdynamic clampestradiolGABApostsynaptic potentialpotassium currents

Identifiers

PMID31628184
PMCPMC6880461
OpenAlexW2981304434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.