ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Cochlear Efferent Innervation Is Sparse in Humans and Decreases with Age.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Temporal Modulation Enhances Medial Olivocochlear Reflex Efficacy: A TEOAE Suppression Study With Amplitude-Modulated Broadband Noise.Brain and behavior · 2026Article
- Auditory Network Discoherence in Chronic Tinnitus.medRxiv : the preprint server for health sciences · 2026Article
- Cochlear histopathology in macaques after noise-induced temporary threshold shifts.Hearing research · 2026Article
- Electrocochleographic Changes Predict an Early Sign of Cochlear Degeneration.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Modeling the impact of cochlear nerve degeneration on speech recognition performance.PloS one · 2025Article
- Human Olivocochlear Effects: A Statistical Detection Approach Applied to the Cochlear Microphonic Evoked by Swept Tones.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Effects of Age on Responses of Principal Cells of the Mouse Anteroventral Cochlear Nucleus in Quiet and Noise.eNeuro · 2024Article
- Effects of contralateral noise on envelope-following responses, auditory-nerve compound action potentials, and otoacoustic emissions measured simultaneously.The Journal of the Acoustical Society of America · 2024Article
- Age-related changes in olivocochlear efferent innervation in gerbils.Frontiers in synaptic neuroscience · 2024Article
- Genetic tools for studying cochlear inhibition.Frontiers in cellular neuroscience · 2024Review
- Age-related alterations in efferent medial olivocochlear-outer hair cell and primary auditory ribbon synapses in CBA/J mice.Frontiers in cellular neuroscience · 2024Article
- The Stria Vascularis in Mice and Humans Is an Early Site of Age-Related Cochlear Degeneration, Macrophage Dysfunction, and Inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Molecular and Functional Changes to Postsynaptic Cholinergic Signaling in the Vestibular Sensory Organs of Aging C57BL/6 Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dopaminergic and cholinergic innervation in the mouse cochlea after noise-induced or age-related synaptopathy.Hearing research · 2022Article
- The α9α10 nicotinic acetylcholine receptor: a compelling drug target for hearing loss?Expert opinion on therapeutic targets · 2022Review
- Direct Cochlear Recordings in Humans Show a Theta Rhythmic Modulation of Auditory Nerve Activity by Selective Attention.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Understanding degraded speech leads to perceptual gating of a brainstem reflex in human listeners.PLoS biology · 2021Article
- The effect of broadband elicitor laterality on psychoacoustic gain reduction across signal frequency.The Journal of the Acoustical Society of America · 2021Article
- Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway.Pflugers Archiv : European journal of physiology · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian cochlea is innervated by two cholinergic feedback systems called the medial olivocochlear (MOC) and lateral olivocochlear (LOC) pathways, which send control signals from the brainstem back to the outer hair cells and auditory-nerve fibers, respectively. Despite countless studies of the cochlear projections of these efferent fibers in animal models, comparable data for humans are almost completely lacking. Here, we immunostained the cochlear sensory epithelium from 23 normal-aging humans (14 males and 9 females), 0-86 years of age, with cholinergic markers to quantify the normal density of MOC and LOC projections, and the degree of age-related degeneration. In younger ears, the MOC density peaks in mid-cochlear regions and falls off both apically and basally, whereas the LOC innervation peaks near the apex. In older ears, MOC density decreases dramatically, whereas the LOC density does not. The loss of MOC feedback may contribute to the age-related decrease in word recognition in noise; however, even at its peak, the MOC density is lower than in other mammals, suggesting the MOC pathway is less important for human hearing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.