Evidence map›Paper›PMID 31628141›Full record

ArticleBiology open2019

Heparan sulfate negatively regulates intestinal stem cell proliferation in

Hubing Ma, Huiqing Zhao, Fuli Liu, Hang Zhao, Ruiyan Kong, Lin Shi, Min Wei, Zhouhua Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Insect Gut Regeneration.Cold Spring Harbor perspectives in biology · 2022
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hubing MaCollege of Life Sciences, Capital Normal University, Beijing 100048, China.
Huiqing ZhaoCollege of Life Sciences, Capital Normal University, Beijing 100048, China.
Fuli LiuCollege of Life Sciences, Capital Normal University, Beijing 100048, China.
Hang ZhaoCollege of Life Sciences, Capital Normal University, Beijing 100048, China.
Ruiyan KongCollege of Life Sciences, Capital Normal University, Beijing 100048, China.
Lin ShiCollege of Life Sciences, Capital Normal University, Beijing 100048, China.
Min WeiCollege of Life Sciences, Capital Normal University, Beijing 100048, China.
Zhouhua LiCollege of Life Sciences, Capital Normal University, Beijing 100048, China zhli@cnu.edu.cn.ORCID http://orcid.org/0000-0002-7660-8579
Capital Normal University · CN

Funding

Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
NIGMS NIH HHS R01 GM084947
6 · The paper itself

Abstract

Tissue homeostasis is maintained by differentiated progeny of residential stem cells. Both extrinsic signals and intrinsic factors play critical roles in the proliferation and differentiation of adult intestinal stem cells (ISCs). However, how extrinsic signals are transduced into ISCs still remains unclear. Here, we find that heparan sulfate (HS), a class of glycosaminoglycan (GAG) chains, negatively regulates progenitor proliferation and differentiation to maintain midgut homeostasis under physiological conditions. Interestingly, HS depletion in progenitors results in inactivation of Decapentaplegic (Dpp) signaling. Dpp signal inactivation in progenitors resembles

Indexed as

Dpp signalingDrosophilaHeparan sulfateIntestinal stem cellTissue homeostasis

Identifiers

PMID31628141
PMCPMC6826283
OpenAlexW2980885917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.