Evidence map›Paper›PMID 31628111›Full record

ArticleDevelopment (Cambridge, England)2019

Repression of an activity-dependent autocrine insulin signal is required for sensory neuron development in

Lauren Bayer Horowitz, Julia P Brandt, Niels Ringstad

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Food sensing controlsScience advances · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. An intraflagellar transport dependent negative feedback regulates the MAPKKK DLK-1 to protect cilia from degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
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  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lauren Bayer HorowitzSkirball Institute of Biomolecular Medicine, Helen L. and Martin S. Kimmel Center for Biology and Medicine, Department of Cell Biology, Neuroscience Institute, NYU School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-0385-7555
Julia P BrandtSkirball Institute of Biomolecular Medicine, Helen L. and Martin S. Kimmel Center for Biology and Medicine, Department of Cell Biology, Neuroscience Institute, NYU School of Medicine, New York, NY 10016, USA.ORCID 0000-0003-4264-9855
Niels RingstadSkirball Institute of Biomolecular Medicine, Helen L. and Martin S. Kimmel Center for Biology and Medicine, Department of Cell Biology, Neuroscience Institute, NYU School of Medicine, New York, NY 10016, USA Niels.Ringstad@med.nyu.edu.ORCID 0000-0002-8679-2269

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular genetics of sensory modulation of motor programsR35GM122573 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Niels Ringstad · 2017 to 2026
$5.7M
Toll-like receptor signaling in sensory neuron differentiation and function.R01GM113182 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RINGSTAD, NIELS · 2014 to 2017
$1.3M
Molecular mechanisms that regulate p38 MAPK-dependent neuronal gene expressionF31NS100360 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOROWITZ, LAUREN BAYER · 2017 to 2019
$134k
NIGMS NIH HHS R01 GM113182NIGMS NIH HHS R35 GM122573NIH HHS P40 OD010440NINDS NIH HHS F31 NS100360
6 · The paper itself

Abstract

Nervous system development is instructed by genetic programs and refined by distinct mechanisms that couple neural activity to gene expression. How these processes are integrated remains poorly understood. Here, we report that the regulated release of insulin-like peptides (ILPs) during development of the

Indexed as

Gene Expression Regulation, DevelopmentalAllelesAnimalsAutocrine CommunicationCaenorhabditis elegansCaenorhabditis elegans ProteinsCalciumCell LineageGenotypeGreen Fluorescent ProteinsHeat-Shock ProteinsInsulinMitogen-Activated Protein KinasesMutationNervous SystemPeptidesCaenorhabditis elegans ProteinsCalciumGreen Fluorescent ProteinsHeat-Shock ProteinsInsulinMitogen-Activated Protein KinasesPeptidespmk-3 protein, C elegansC. elegansInsulin signalingNervous system developmentSensory neuron

Identifiers

PMID31628111
PMCPMC6899041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.