Evidence map›Paper›PMID 31627909›Full record

ArticleThe Journal of allergy and clinical immunology2020

Ozone-induced enhancement of airway hyperreactivity in rhesus macaques: Effects of antioxidant treatment.

Cameron H Flayer, Erik D Larson, Anjali Joseph, Sean Kao, Wenxiu Qu, Austin Van Haren, Christopher M Royer, Lisa A Miller, John P Capitanio, Thais Sielecki and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. The "epiTet" of Air Pollution: Epigenetic Regulation of Airway Inflammation by Tet1.International archives of allergy and immunology · 2023
    Article
  4. A Novel Nonhuman Primate Model of Nonatopic Asthma.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  5. A Murine Model of Ozone-induced Nonatopic Asthma from the Collaborative Cross.American journal of respiratory cell and molecular biology · 2021
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Cameron H FlayerPulmonary, Critical Care and Sleep Division, Department of Medicine, UC Davis School of Medicine, Davis, Calif.
Erik D LarsonPulmonary, Critical Care and Sleep Division, Department of Medicine, UC Davis School of Medicine, Davis, Calif.
Anjali JosephPulmonary, Critical Care and Sleep Division, Department of Medicine, UC Davis School of Medicine, Davis, Calif.
Sean KaoPulmonary, Critical Care and Sleep Division, Department of Medicine, UC Davis School of Medicine, Davis, Calif.
Wenxiu QuPulmonary, Critical Care and Sleep Division, Department of Medicine, UC Davis School of Medicine, Davis, Calif; Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang, China.
Austin Van HarenPulmonary, Critical Care and Sleep Division, Department of Medicine, UC Davis School of Medicine, Davis, Calif.
Christopher M RoyerUC Davis California National Primate Research Center, Davis, Calif.
Lisa A MillerUC Davis California National Primate Research Center, Davis, Calif.
John P CapitanioUC Davis California National Primate Research Center, Davis, Calif.
Thais SieleckiLignaMed, Philadelphia, Pa.
Melpo Christofidou-SolomidouPulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pa.
Angela HaczkuPulmonary, Critical Care and Sleep Division, Department of Medicine, UC Davis School of Medicine, Davis, Calif. Electronic address: haczku@ucdavis.edu.
University of California, Davis · USUniversity of Pennsylvania · US

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Ameer Taha · 2015 to 2026
$26.0M
TRAINING IN COMPARATIVE LUNG BIOLOGY AND MEDICINET32HL007013 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI Elena Goncharova, Nicholas J. KENYON · 1985 to 2026
$10.1M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
IND enabling development of LGM2605 as adjuvant treatment for asthmaR42AI132012 · NIAID · LIGNAMED, LLC · PI HACZKU, ANGELA, SIELECKI, THAIS MOTRIA · 2019 to 2021
$3.0M
Biobehavioral characterization of infant rhesus monkeysR24OD010962 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CAPITANIO, JOHN P · 2012 to 2018
$2.5M
Age-Dependent Effects of E-cigarette Vaping on Host Pathogen DefenseK01OD024782 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ROYER, CHRISTOPHER MICHAEL · 2017 to 2021
$737k
Asthma, anxiety and GR abnormalities in non-human primatesR21AI116121 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HACZKU, ANGELA · 2015 to 2016
$448k
Effects of LGM2605 on a Primate Model of AsthmaR41AI132012 · NIAID · LIGNAMED, LLC · PI HACZKU, ANGELA, SIELECKI, THAIS MOTRIA · 2017 to 2017
$278k
NHLBI NIH HHS T32 HL007013NIAID NIH HHS R21 AI116121NIAID NIH HHS R41 AI132012NIAID NIH HHS R42 AI132012NIEHS NIH HHS P30 ES013508NIEHS NIH HHS P30 ES023513NIEHS NIH HHS T32 ES007059NIH HHS P51 OD011107NIH HHS R24 OD010962
6 · The paper itself

Abstract

backgroundOzone (O

objectivesWe sought to investigate mucosal immune changes after O

methodsA cohort of macaques (n = 17) previously characterized with airway hyperreactivity (AHR) to methacholine was assessed (day 1). Macaques were treated (orally) with LGM2605 (25 mg/kg) or placebo twice per day for 7 days, exposed to 0.3 ppm O

resultsO

conclusionILC2s, CD1c

Indexed as

AnimalsAntioxidantsAsthmaButylene GlycolsCD4-Positive T-LymphocytesDendritic CellsFemaleGlucosidesMacaca mulattaMaleMyeloid CellsOzoneAntioxidantsButylene GlycolsGlucosidesLGM2605Ozoneair pollutionairway inflammationAsthmanonhuman primatetherapies (investigational)

Identifiers

PMID31627909
PMCPMC6949398
OpenAlexW2980979057

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.