Evidence map›Paper›PMID 31627841›Full record

ReviewCellular immunology2019

Diminished immune responses with aging predispose older adults to common and uncommon influenza complications.

Spencer R Keilich, Jenna M Bartley, Laura Haynes

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.

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  9. ApoD mediates age-associated increase in vulnerability to influenza virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Spencer R KeilichUConn Center on Aging, University of Connecticut School of Medicine, Farmington, CT 06030, USA. Electronic address: keilich@uchc.edu.
Jenna M BartleyUConn Center on Aging, University of Connecticut School of Medicine, Farmington, CT 06030, USA; Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030, USA. Electronic address: jbartley@uchc.edu.
Laura HaynesUConn Center on Aging, University of Connecticut School of Medicine, Farmington, CT 06030, USA; Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030, USA. Electronic address: lhaynes@uchc.edu.
University of Connecticut · US

Funding

MOLECULAR BIOLOGY COREP01AG021600 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HAYNES, LAURA · 2003 to 2016
$24.4M
Impact of Aging and Influenza Infection on Muscle HealthR21AG060389 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HAYNES, LAURA · 2018 to 2019
$456k
NIA NIH HHS P01 AG021600NIA NIH HHS R21 AG060389
6 · The paper itself

Abstract

Influenza (flu) is a serious disease for older adults, with increased severity of infection and greater risk for hospitalization and death. Flu infection is limited to pulmonary epithelial cells, yet there are many systemic symptoms and older adults are more susceptible to flu-related complications. In older adults, flu rarely comes without additional complications and there is a perfect storm for enhanced disease due to multiple factors including existing co-morbidities, plus impaired lung function and dysregulated immune responses that occur with even healthy aging. Commonly, opportunistic secondary bacterial infections prosper in damaged lungs. Intensified systemic inflammation with aging can cause dysfunction in extra-pulmonary organs and tissues such as cardiovascular, musculoskeletal, neuropathologic, hepatic, and renal complications. Often overlooked is the underappreciated connections between many of these conditions, which exacerbate one another when in parallel. This review focuses on flu infection and the numerous complications in older adults associated with diminished immune responses.

Indexed as

AgedAgingBacterial InfectionsCardiovascular DiseasesDisease SusceptibilityHumansImmunityInflammationInfluenza, HumanNervous System DiseasesAgingCardiovascularHepaticImmunologyInfluenzaMusculoskeletalNeuropathologicRenalSecondary bacteria infection

Identifiers

PMID31627841
PMCPMC6939636
OpenAlexW2979561099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.