Evidence map›Paper›PMID 31627773›Full record

Trial reportThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2019

Challenges in conducting trials for pediatric tuberculous meningitis: lessons from the field.

M Paradkar, D B Devaleenal, T Mvalo, A Arenivas, K T Thakur, S Afrin, P Giridharan, E Selladurai, A Kinikar, C Valvi and 3 more

Open access · greenAbstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Trial
  3. Article
  4. Performance of XpertThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

M ParadkarByramjee Jeejeebhoy Government Medical College-Johns Hopkins Clinical Research Site, Pune.
D B DevaleenalNational Institute for Research in Tuberculosis, Indian Council for Medical Research, Chennai, India.
T MvaloUniversity of North Carolina Project-Malawi, Lilongwe, Malawi, Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, NC.
A ArenivasThe Institute for Rehabilitation and Research Memorial Hermann, Department of Rehabilitation Psychology and Neuropsychology, Houston, TX, Baylor College of Medicine, Department of Physical Medicine and Rehabilitation, Houston, TX.
K T ThakurDepartment of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
S AfrinByramjee Jeejeebhoy Government Medical College-Johns Hopkins Clinical Research Site, Pune.
P GiridharanNational Institute for Research in Tuberculosis, Indian Council for Medical Research, Chennai, India.
E SelladuraiInstitute of Child Health and Hospital for Children, Chennai.
A KinikarByramjee Jeejeebhoy Government Medical College-Johns Hopkins Clinical Research Site, Pune, BJ Government Medical College, Pune, India.
C ValviByramjee Jeejeebhoy Government Medical College-Johns Hopkins Clinical Research Site, Pune, BJ Government Medical College, Pune, India.
A GuptaJohns Hopkins University School of Medicine, Baltimore, MD, USA.
V MaveByramjee Jeejeebhoy Government Medical College-Johns Hopkins Clinical Research Site, Pune, BJ Government Medical College, Pune, India.
K E DooleyJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Government Medical College · INNational Institute of Research in Tuberculosis · INColumbia University · USInstitute of Child Health · INJohns Hopkins Medicine · USJohns Hopkins University · USMemorial Hermann Institute for Rehabilitation and Research Foundation · USUniversity of North Carolina at Chapel Hill · US

Funding

Innovative PK/PD Approaches to Optimize TBM Treatment in Children (PATCH Study)R01HD074944 · NICHD · JOHNS HOPKINS UNIVERSITY · PI DOOLEY, KELLY E. · 2014 to 2019
$2.5M
Mentoring Investigators in HIV and Tuberculosis Therapeutics ResearchK24AI150349 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DOOLEY, KELLY E. · 2020 to 2025
$789k
NIAID NIH HHS K24 AI150349NICHD NIH HHS R01 HD074944
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Research DesignAntitubercular AgentsCaregiversChildChild, PreschoolFollow-Up StudiesHumansIndiaInfantMalawiTuberculosis, MeningealAntitubercular Agents

Identifiers

PMID31627773
PMCPMC9635884
OpenAlexW2980829553

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.