Evidence map›Paper›PMID 31627723›Full record

Trial reportBMC musculoskeletal disorders2019

The effect of mobilization with movement on pain and function in patients with knee osteoarthritis: a randomized double-blind controlled trial.

Hani A Alkhawajah, Ali M Alshami

2 registry-linked trialsOpen access · goldAbstract readClinical Trial, Phase IRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 6 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02865252 phase1completednot on this map

The Effect of Mobilization With Movement on Pain and Function Among Patients With Knee Osteoarthritis

TypeinterventionalSponsorImam Abdulrahman Bin Faisal UniversityRan2015Enrolled38ConditionsOsteoarthritisArmsMWM Treatment, MWM Sham
NCT04940715 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Efficacy of Passive Joint Mobilization vs Mobilization With Movement on Pain Processing in Patients With Chronic Low Back Pain: a Double-blinded, Randomized Clinical Trial.

TypeinterventionalSponsorUniversidad Rey Juan CarlosRan2021 to 2022Enrolled54ConditionsChronic Low-back PainArmsPassive joint mobilization, Mobilization with movement
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Exercise for osteoarthritis of the knee.The Cochrane database of systematic reviews · 2024
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  14. Prolotherapy for temporomandibular joint disorders: an updated comprehensive review.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hani A AlkhawajahDepartment of Physiotherapy, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, P.O Box 40244, Khobar, 31952, Saudi Arabia. hkhawajah@iau.edu.sa.ORCID http://orcid.org/0000-0001-5601-8240
Ali M AlshamiDepartment of Physical Therapy, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, P.O. Box 2435, Dammam, 31441, Saudi Arabia.
Imam Abdulrahman Bin Faisal University · SAKing Fahd Hospital of the University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew studies have investigated the effects of mobilization with movement (MWM) in patients with knee osteoarthritis (OA) compared to other procedures. Sham procedures are generally more appropriate control than using no or usual treatments. Moreover, studies investigating the widespread hypoalgesic effects of MWM in patients with knee OA are lacking. The aim was to investigate the effect of MWM on function and pain in patients with knee OA compared to sham MWM.

methodsThis is a randomized double-blind (patients and assessor) controlled trial. Forty adult patients with knee OA of grade II and above were recruited to receive either MWM treatment or sham MWM for the knee. The outcome measures included the following: a visual analogue scale (VAS) for pain, the pressure pain threshold (PPT) test, the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index, the timed up and go (TUG) test, knee strength and knee range of motion (ROM). The measurements were taken at baseline, immediately after intervention and 2 days later.

resultsCompared with sham MWM, MWM resulted in greater immediate improvement in pain [mean difference (95% CI): - 2.2 (- 2.8, - 1.6)], PPT at both the knee [176 (97, 254)] and shoulder [212 (136, 288)], TUG time [- 1.6 (- 2.1, - 1.1)], knee flexor strength [2.0 (1.3, 2.7)] and extensor strength [5.7 (4.1, 7.2)] and knee flexion ROM [12.8 (9.6, 15.9)] (all, p < 0.001) but not knee extension ROM [- 0.8 (- 1.6, 0.1)] (p = 0.067). After 2 days of intervention, patients who received MWM also demonstrated a greater improvement in pain [- 1.0 (- 1.8, - 0.1)], PPT at the shoulder [107 (40, 175)], TUG time [- 0.9 (- 1.4, - 0.4)], knee flexor strength [0.9 (0.2, 1.7)] and extensor strength [2.9 (2.1, 3.9)] and knee flexion ROM [8.3 (4.7, 11.9)] (all, p ≤ 0.026). However, WOMAC scores and knee extension ROM showed no evidence of change at any stage after intervention (p ≥ 0.067).

conclusionsMWM provided superior benefits over sham MWM in terms of local and widespread pain, physical function (walking), knee flexion and extension muscle strength and knee flexion ROM for at least 2 days in patients with knee OA.

trial registrationClinicalTrials.gov ( NCT02865252 ), registered on August 12, 2016.

Indexed as

Range of Motion, ArticularArthralgiaDouble-Blind MethodFemaleHumansKnee JointMaleManipulation, OrthopedicMiddle AgedOsteoarthritis, KneePain MeasurementTreatment OutcomeHypoalgesiaManual therapyPressure pain thresholdQuantitative sensory testing

Identifiers

PMID31627723
PMCPMC6800493
OpenAlexW2980625866

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.