Evidence map›Paper›PMID 31627436›Full record

ArticleCancers2019

The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells.

Anna S Kirstein, Adrien Augustin, Melanie Penke, Michele Cea, Antje Körner, Wieland Kiess, Antje Garten

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Overgrowth syndromes and new therapies.Seminars in pediatric surgery · 2020
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Anna S KirsteinPediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103 Leipzig, Germany. anna.kirstein@medizin.uni-leipzig.de.ORCID 0000-0002-3554-1902
Adrien AugustinPediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103 Leipzig, Germany. adrien.augustin@student.uliege.be.
Melanie PenkePediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103 Leipzig, Germany. melanie.penke@medizin.uni-leipzig.de.
Michele CeaChair of Hematology, Department of Internal Medicine (DiMI), University of Genoa, 16100 Genoa, Italy. michele.cea@unige.it.ORCID 0000-0002-1530-6729
Antje KörnerPediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103 Leipzig, Germany. antje.koerner@medizin.uni-leipzig.de.
Wieland KiessPediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103 Leipzig, Germany. wieland.kiess@medizin.uni-leipzig.de.
Antje GartenPediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103 Leipzig, Germany. antje.garten@medizin.uni-leipzig.de.ORCID 0000-0002-5354-287X
Leipzig University · DEOspedale Policlinico San Martino · ITUniversity of Birmingham · GBUniversity of Liège · BE

Funding

Bundesministerium für Bildung und Forschung FKZ: 464 01EO1501, IFB project AD2-7105Deutsche Forschungsgemeinschaft 209933838 - SFB 1052Erasmus+ 2018-1-BE01-KA103-038469
6 · The paper itself

Abstract

Germline mutations in the tumor suppressor gene

Indexed as

AKTlipomamTORovergrowthPHTSproliferationPROSrapamycinribosomal protein S6spheroids

Identifiers

PMID31627436
PMCPMC6826943
OpenAlexW2978559867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.