ArticleInternational journal of molecular sciences2019
A Cellularized Biphasic Implant Based on a Bioactive Silk Fibroin Promotes Integration and Tissue Organization during Osteochondral Defect Repair in a Porcine Model.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Bioengineered Tricomposite Hydrogel Enhances Chondrogenic Phenotype and Hyaline Matrix Formation in Human Chondrocytes.Gels (Basel, Switzerland) · 2025Article
- An Overview of Approaches and Evaluation Methods for Tissue-Engineered Articular Cartilage Constructs in Animal Models.Annals of biomedical engineering · 2025Review
- Osteochondral tissue engineering‑based subchondral bone plate repair (Review).Molecular medicine reports · 2025Review
- Osteochondral tissue engineering in translational practice: histological assessments and scoring systems.Frontiers in bioengineering and biotechnology · 2024Review
- Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration.Bioactive materials · 2023Article
- Performance of Colombian Silk Fibroin Hydrogels for Hyaline Cartilage Tissue Engineering.Journal of functional biomaterials · 2022Article
- Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.ACS applied materials & interfaces · 2022Article
- Sequential growth factor exposure of human Ad-MSCs improves chondrogenic differentiation in an osteochondral biphasic implant.Experimental and therapeutic medicine · 2021Article
- Osteochondral tissue engineering: Perspectives for clinical application and preclinical development.Journal of orthopaedic translation · 2021Review
- Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling.Frontiers in bioengineering and biotechnology · 2021Review
- Peripheral mechanisms of arthritic pain: A proposal to leverage large animals forNeurobiology of pain (Cambridge, Mass.)Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
In cartilage tissue engineering, biphasic scaffolds (BSs) have been designed not only to influence the recapitulation of the osteochondral architecture but also to take advantage of the healing ability of bone, promoting the implant's integration with the surrounding tissue and then bone restoration and cartilage regeneration. This study reports the development and characterization of a BS based on the assembly of a cartilage phase constituted by fibroin biofunctionalyzed with a bovine cartilage matrix, cellularized with differentiated autologous pre-chondrocytes and well attached to a bone phase (decellularized bovine bone) to promote cartilage regeneration in a model of joint damage in pigs. BSs were assembled by fibroin crystallization with methanol, and the mechanical features and histological architectures were evaluated. The scaffolds were cellularized and matured for 12 days, then implanted into an osteochondral defect in a porcine model (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.