Evidence map›Paper›PMID 31627272›Full record

ArticleInternational journal of molecular sciences2019

Programmed Death Ligand 1 Indicates Pre-Existing Adaptive Immune Response by Tumor-Infiltrating CD8

Yi-Ming Li, Jing-Min Yu, Zhen-Yu Liu, Hai-Jiao Yang, Juan Tang, Zhi-Nan Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. T cell adaptation in chronic infections and tumors.Cellular & molecular immunology · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. PD-L1 in Combination with CD8Cancer management and research · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yi-Ming LiNational Translational Science Center for Molecular Medicine, Xi'an 710032, China. sydlym@163.com.
Jing-Min YuNational Translational Science Center for Molecular Medicine, Xi'an 710032, China. yujingmin1226@163.com.
Zhen-Yu LiuNational Translational Science Center for Molecular Medicine, Xi'an 710032, China. qqqzhenyu20052008@163.com.
Hai-Jiao YangNational Translational Science Center for Molecular Medicine, Xi'an 710032, China. yhjjqq.love@163.com.
Juan TangNational Translational Science Center for Molecular Medicine, Xi'an 710032, China. tangjuan1@fmmu.edu.cn.
Zhi-Nan ChenNational Translational Science Center for Molecular Medicine, Xi'an 710032, China. znchen@fmmu.edu.cn.
Air Force Medical University · CN

Funding

National Natural Science Foundation of China 81472700National Natural Science Foundation of China 81872316National Science and Technology Major Special Project of China 2018ZX09101001Shaanxi Science and Technology New Star Project 2017KJXX-68
6 · The paper itself

Abstract

Aberrant expression of programmed death ligand 1 (PD-L1) on tumor cells impedes antitumor immunity and instigates immune evasion. The remarkable efficacy of immune checkpoint blockade has been confirmed in various solid tumors. However, the correlation between PD-L1 expression and host immunological landscape remains of considerable controversy in non-small cell lung cancer (NSCLC). In the present study, PD-L1 expression and CD8

Indexed as

Adaptive ImmunityAgedB7-H1 AntigenCarcinoma, Non-Small-Cell LungCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansInterferon-gammaMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsRegression AnalysisSignal TransductionTumor Cells, CulturedB7-H1 AntigenCD274 protein, humanInterferon-gammaIFN-γNSCLCPD-L1tumor infiltrating lymphocytes

Identifiers

PMID31627272
PMCPMC6829548
OpenAlexW2980387286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.