ArticleCortex; a journal devoted to the study of the nervous system and behavior2019
Treatment-related changes in neural activation vary according to treatment response and extent of spared tissue in patients with chronic aphasia.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Network flexibility facilitates treatment-induced recovery in post-stroke aphasia.Brain communications · 2026Article
- Test-retest reliability of edge-level resting-state functional connectivity in people with aphasia.Neuroimage. Reports · 2025Article
- Independent contributions of language activations in left and right temporal cortex to aphasia outcomes after stroke.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Using unsupervised dimensionality reduction to identify lesion patterns predictive of post-stroke aphasia severity.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Evolution of Word Production Errors after Typicality-Based Semantic Naming Treatment in Individuals with Aphasia.Aphasiology · 2025Article
- Promoting Augmentative and Alternative Communication-Induced Language Recovery in Chronic Aphasia (PAIL-RcA): Theoretical Construct, Method, Protocol, and Treatment Resources.American journal of speech-language pathology · 2025Article
- Aphasia rehabilitation: a narrative review of adjuvant techniques.Frontiers in human neuroscience · 2025Review
- Resting-state brain network connectivity is an independent predictor of responsiveness to language therapy in chronic post-stroke aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Disentangling neuroplasticity mechanisms in post-stroke language recovery.Brain and language · 2024Review
- Pars Opercularis Underlies Efferent Predictions and Successful Auditory Feedback Processing in Speech: Evidence From Left-Hemisphere Stroke.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Cerebral Small Vessel Disease Burden: An Independent Biomarker for Anomia Treatment Responsiveness in Chronic Stroke Patients With Aphasia.Archives of physical medicine and rehabilitation · 2023Article
- Treatment-induced neural reorganization in aphasia is language-domain specific: Evidence from a large-scale fMRI study.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Is there a Relationship Between Cortisol and Treatment Response in Chronic Aphasia?Topics in language disorders · 2022Article
- White matter microstructural integrity pre- and post-treatment in individuals with chronic post-stroke aphasia.Brain and language · 2022Article
- Understanding, facilitating and predicting aphasia recovery after rehabilitation.International journal of speech-language pathology · 2022Review
- Multimodal Neural and Behavioral Data Predict Response to Rehabilitation in Chronic Poststroke Aphasia.Stroke · 2022Article
- Perilesional Perfusion in Chronic Stroke-Induced Aphasia and Its Response to Behavioral Treatment Interventions.Neurobiology of language (Cambridge, Mass.) · 2022Article
- Neural correlates of syntactic comprehension: A longitudinal study.Brain and language · 2022Article
- Abnormally weak functional connections get stronger in chronic stroke patients who benefit from naming therapy.Brain and language · 2021Article
Corrections and comments
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4 authors.
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Abstract
Neuroimaging studies of aphasia recovery have linked treatment-related improvements in language processing to changes in functional brain activation in left hemisphere language regions and their right hemisphere homologues. Although there is some consensus that better behavioral outcomes are achieved when activation is restored to the left hemisphere, the circumstances that dictate how and why regions in both hemispheres respond to naming therapy are still unclear. In this study, an fMRI picture-naming task was used to examine 16 regions of interest in 26 patients with chronic aphasia before and after 12 weeks of semantic naming treatment. Ten control patients who did not receive treatment and 17 healthy controls were also scanned. Naming therapy resulted in a significant increase in cortical activation, an effect that was largely driven by patients who responded most favorably to treatment, as patients who responded less favorably (as well as those who did not receive treatment) had little change in activation over time. Relative to healthy controls, patients had higher pre-treatment activation in the bilateral inferior frontal gyri (IFG) and lower activation in the bilateral angular gyri; after treatment, they had higher activation in bilateral IFG, as well as in the right middle frontal gyrus. These results suggest that the predominant effect of beneficial naming treatment was an upregulation of traditional language areas and their right hemisphere homologues and, in particular, regions associated with phonological and semantic/executive semantic processing, as well as broader domain general functions. Additionally, in some left hemisphere regions, post-treatment changes in activation were greater when there was more damage than when there was less damage, indicating that spared tissue in otherwise highly damaged regions can be modulated by treatment.
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